Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin

Toufeeq Imtiaz, Kathy K Lee, Carol A Munro, Donna M Maccallum, Gillian S Shankland, Elizabeth M Johnson, Mark S Macgregor, Abhijit M Bal

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15 Citations (Scopus)

Abstract

Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream Candida albicans infection with both Fks1 hotspot mutation and elevated cell wall chitin.
Original languageEnglish
Pages (from-to)1330-1334
Number of pages5
JournalJournal of Medical Microbiology
Volume61
Issue number9
Early online date31 May 2012
DOIs
Publication statusPublished - Sep 2012

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