Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin

Toufeeq Imtiaz; Kathy K Lee; Carol A Munro; Donna M Maccallum; Gillian S Shankland; Elizabeth M Johnson; Mark S Macgregor; Abhijit M Bal

doi:10.1099/jmm.0.045047-0

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin

Toufeeq Imtiaz, Kathy K Lee, Carol A Munro, Donna M Maccallum, Gillian S Shankland, Elizabeth M Johnson, Mark S Macgregor, Abhijit M Bal

Medical Sciences

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28 Citations (Scopus)

Abstract

Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream Candida albicans infection with both Fks1 hotspot mutation and elevated cell wall chitin.

Original language	English
Pages (from-to)	1330-1334
Number of pages	5
Journal	Journal of Medical Microbiology
Volume	61
Issue number	9
Early online date	31 May 2012
DOIs	https://doi.org/10.1099/jmm.0.045047-0
Publication status	Published - Sept 2012

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Imtiaz, T., Lee, K. K., Munro, C. A., Maccallum, D. M., Shankland, G. S., Johnson, E. M., Macgregor, M. S., & Bal, A. M. (2012). Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin. Journal of Medical Microbiology, 61(9), 1330-1334. https://doi.org/10.1099/jmm.0.045047-0

Imtiaz, T, Lee, KK, Munro, CA , Maccallum, DM, Shankland, GS, Johnson, EM, Macgregor, MS & Bal, AM 2012, 'Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin', Journal of Medical Microbiology, vol. 61, no. 9, pp. 1330-1334. https://doi.org/10.1099/jmm.0.045047-0

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abstract = "Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream Candida albicans infection with both Fks1 hotspot mutation and elevated cell wall chitin.",

author = "Toufeeq Imtiaz and Lee, {Kathy K} and Munro, {Carol A} and Maccallum, {Donna M} and Shankland, {Gillian S} and Johnson, {Elizabeth M} and Macgregor, {Mark S} and Bal, {Abhijit M}",

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AU - Munro, Carol A

AU - Maccallum, Donna M

AU - Shankland, Gillian S

AU - Johnson, Elizabeth M

AU - Macgregor, Mark S

AU - Bal, Abhijit M

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Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin

Abstract

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