Echocardiographic indices of elevated left ventricular filling pressure and left ventricular dilation after reperfused acute myocardial infarction.

Graham Scott Hillis, K. Ujino, S. L. Mulvagh, M. E. Hagen, J. K. Oh

    Research output: Contribution to journalArticle

    49 Citations (Scopus)

    Abstract

    The relationship between echocardiographic indicators of acute and chronic left ventricular (LV) filling pressure and LV dilation after acute myocardial infarction was assessed in 47 patients. The ratio of early transmittal flow velocity to early mitral annulus velocity E/e') reflects acute LV filling pressure and the indexed volume of the left atrium is an indicator of chronic LV filling pressure. E/e' was higher (19 vs 10, P =.001) among patients who experienced a greater than 15% increase in indexed LV end-diastolic volume (remodeling group, n = 10). Receiver operating characteristic curve analysis confirmed that E/e' was a predictor of remodeling (area under the curve 0.83, P =.002). Patients with E/e' greater than 15 had a mean increase in indexed LV end-diastolic volume of 9.3 versus 1.7 mL/m(2) in patients with E/e' 15 or less (P =.01). Multivariable regression analyses confirmed that E/e' was the strongest independent predictor of remodeling in this cohort (odds ratio 1.39, P =.01). There was no relationship between indexed volume of the left atrium and LV dilation. These data suggest that the E/e' ratio may be a useful predictor of LV dilation after acute myocardial infarction. In particular, an E/e' ratio greater than 15 identifies patients at increased risk.

    Original languageEnglish
    Pages (from-to)450-456
    Number of pages6
    JournalJournal of the American Society of Echocardiography
    Volume19
    DOIs
    Publication statusPublished - 2006

    Keywords

    • LEFT ATRIAL VOLUME
    • MITRAL DECELERATION TIME
    • DIASTOLIC FUNCTION
    • DOPPLER-ECHOCARDIOGRAPHY
    • PROGNOSTIC IMPLICATIONS
    • NONINVASIVE ASSESSMENT
    • POWERFUL PREDICTOR
    • SURVIVAL
    • CARDIOMYOPATHY
    • RELAXATION

    Cite this

    Echocardiographic indices of elevated left ventricular filling pressure and left ventricular dilation after reperfused acute myocardial infarction. / Hillis, Graham Scott; Ujino, K.; Mulvagh, S. L.; Hagen, M. E.; Oh, J. K.

    In: Journal of the American Society of Echocardiography, Vol. 19, 2006, p. 450-456.

    Research output: Contribution to journalArticle

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    AU - Hagen, M. E.

    AU - Oh, J. K.

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    AB - The relationship between echocardiographic indicators of acute and chronic left ventricular (LV) filling pressure and LV dilation after acute myocardial infarction was assessed in 47 patients. The ratio of early transmittal flow velocity to early mitral annulus velocity E/e') reflects acute LV filling pressure and the indexed volume of the left atrium is an indicator of chronic LV filling pressure. E/e' was higher (19 vs 10, P =.001) among patients who experienced a greater than 15% increase in indexed LV end-diastolic volume (remodeling group, n = 10). Receiver operating characteristic curve analysis confirmed that E/e' was a predictor of remodeling (area under the curve 0.83, P =.002). Patients with E/e' greater than 15 had a mean increase in indexed LV end-diastolic volume of 9.3 versus 1.7 mL/m(2) in patients with E/e' 15 or less (P =.01). Multivariable regression analyses confirmed that E/e' was the strongest independent predictor of remodeling in this cohort (odds ratio 1.39, P =.01). There was no relationship between indexed volume of the left atrium and LV dilation. These data suggest that the E/e' ratio may be a useful predictor of LV dilation after acute myocardial infarction. In particular, an E/e' ratio greater than 15 identifies patients at increased risk.

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