TY - JOUR
T1 - EEG Gamma Band Alterations and REM-like Traits Underpin the Acute Effect of the Atypical Psychedelic Ibogaine in the Rat
AU - González, Joaquín
AU - Cavelli, Matias
AU - Castro-Zaballa, Santiago
AU - Mondino, Alejandra
AU - Tort, Adriano B. L.
AU - Rubido, Nicolás
AU - Carrera, Ignacio
AU - Torterolo, Pablo
N1 - ACKNOWLEDGMENTS
This study was supported by the Programa de Desarrollo de Ciencias Básicas, PEDECIBA; Agencia Nacional de Investigación e Innovación (ANII), (FCE-1-2017-1-136550) and the Comisión Sectorial de Investigación Científica (CSIC) I+D-2016-589 grant from Uruguay. J.G was supported by CAP (Comisión Académica de Posgrado). N.R. acknowledges the CSIC group grant CSIC2018 - FID 13 - Grupo ID 722. A.B.L.T. was supported by Conselho
Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenacao de Aperfeicoamento de Pessoal de Nível Superior (CAPES), Brazil
PY - 2021/1/11
Y1 - 2021/1/11
N2 - Ibogaine is a psychedelic alkaloid that has attracted large scientific interest because of its antiaddictive properties in observational studies in humans as well as in animal models. Its subjective effect has been described as intense, vivid dream-like experiences occurring while awake; hence, ibogaine is often referred to as an oneirogenic psychedelic. While this unique dream-like profile has been hypothesized to aid the antiaddictive effects, the electrophysiological signatures of this psychedelic state remain unknown. We previously showed in rats that ibogaine promotes a waking state with abnormal motor behavior along with a decrease in NREM and REM sleep. Here, we performed an in-depth analysis of the intracranial electroencephalogram during “ibogaine wakefulness”. We found that ibogaine induces gamma oscillations that, despite having larger power than control levels, are less coherent and less complex. Further analysis revealed that this profile of gamma activity compares to that of natural REM sleep. Thus, our results provide novel biological evidence for the association between the psychedelic state and REM sleep, contributing to the understanding of the brain mechanisms associated with the oneirogenic psychedelic effect of ibogaine.
AB - Ibogaine is a psychedelic alkaloid that has attracted large scientific interest because of its antiaddictive properties in observational studies in humans as well as in animal models. Its subjective effect has been described as intense, vivid dream-like experiences occurring while awake; hence, ibogaine is often referred to as an oneirogenic psychedelic. While this unique dream-like profile has been hypothesized to aid the antiaddictive effects, the electrophysiological signatures of this psychedelic state remain unknown. We previously showed in rats that ibogaine promotes a waking state with abnormal motor behavior along with a decrease in NREM and REM sleep. Here, we performed an in-depth analysis of the intracranial electroencephalogram during “ibogaine wakefulness”. We found that ibogaine induces gamma oscillations that, despite having larger power than control levels, are less coherent and less complex. Further analysis revealed that this profile of gamma activity compares to that of natural REM sleep. Thus, our results provide novel biological evidence for the association between the psychedelic state and REM sleep, contributing to the understanding of the brain mechanisms associated with the oneirogenic psychedelic effect of ibogaine.
KW - ibogaine
KW - intracranial electroencephalogram
KW - Computational neuroscience
KW - sleep-wake cycle
KW - psychedelics
KW - computational neuroscience
UR - http://www.scopus.com/inward/record.url?scp=85100019806&partnerID=8YFLogxK
U2 - 10.1021/acsptsci.0c00164
DO - 10.1021/acsptsci.0c00164
M3 - Article
C2 - 33860181
VL - 4
SP - 517
EP - 525
JO - ACS Pharmacology & Translational Science
JF - ACS Pharmacology & Translational Science
IS - 2
ER -