Efectiveness of influenza vaccines in Asthma: A systematic review and meta-analysis

Eleftheria Vasileiou; Aziz Sheikh; Chris Butler; Karim El Ferkh; Beatrix Von Wissmann; Jim McMenamin; Lewis Ritchie; Jürgen Schwarze; Nikolaos G. Papadopoulos; Sebastian L. Johnston; Lilly Tian; Colin R. Simpson

doi:10.1093/cid/cix524

Efectiveness of influenza vaccines in Asthma: A systematic review and meta-analysis

Eleftheria Vasileiou^* (Corresponding Author), Aziz Sheikh, Chris Butler, Karim El Ferkh, Beatrix Von Wissmann, Jim McMenamin, Lewis Ritchie, Jürgen Schwarze, Nikolaos G. Papadopoulos, Sebastian L. Johnston, Lilly Tian, Colin R. Simpson

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

96 Citations (Scopus)

6 Downloads (Pure)

Abstract

There is uncertainty about the effectiveness of influenza vaccination in persons with asthma and its impact on asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma. This systematic review and meta-analysis involved searching 12 international databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiological studies (1970-2016). The risk of bias was low for 3 included RCTs. The quality of 3 included observational studies was moderate. The quality of evidence was very low for all study outcomes. Pooled vaccine effectiveness in 1825 persons with asthma from 2 test-negative design case-control studies was 45% (95% confidence interval [CI], 31%-56%) for laboratory-confirmed influenza. Pooled eficacy of live vaccines in reducing influenza was 81% (95% CI, 33%-94%). Live vaccine reduced febrile illness by 72% (95% CI, 20%-90%). Influenza vaccine prevented 59%-78% of asthma attacks leading to emergency visits and/or hospitalizations. For persons with asthma, influenza vaccination may be effective in both reducing influenza infection and asthma attacks.

Original language	English
Pages (from-to)	1388-1395
Number of pages	8
Journal	Clinical Infectious Diseases
Volume	65
Issue number	8
DOIs	https://doi.org/10.1093/cid/cix524
Publication status	Published - 15 Oct 2017

Bibliographical note

The work was funded by the Chief Scientist Office of the Scottish Government under the grant (AUKCAR/14/03). This work is carried out with the support of the Asthma UK Centre for Applied Research (AUK-AC-2012-01).

Keywords

Asthma
Immunization
Influenza
Laboratory confirmed influenza
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cid/cix524Licence: CC BY-NC-ND

Vasileiou_et_al_effectivness_of_influenza_VOR
https://creativecommons.org/licenses/by-nc-nd/4.0/
Final published version, 6.74 MBLicence: CC BY-NC-ND

Cite this

@article{a2665ec981cc4aff958bed5cde60bd5a,

title = "Efectiveness of influenza vaccines in Asthma: A systematic review and meta-analysis",

abstract = "There is uncertainty about the effectiveness of influenza vaccination in persons with asthma and its impact on asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma. This systematic review and meta-analysis involved searching 12 international databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiological studies (1970-2016). The risk of bias was low for 3 included RCTs. The quality of 3 included observational studies was moderate. The quality of evidence was very low for all study outcomes. Pooled vaccine effectiveness in 1825 persons with asthma from 2 test-negative design case-control studies was 45% (95% confidence interval [CI], 31%-56%) for laboratory-confirmed influenza. Pooled eficacy of live vaccines in reducing influenza was 81% (95% CI, 33%-94%). Live vaccine reduced febrile illness by 72% (95% CI, 20%-90%). Influenza vaccine prevented 59%-78% of asthma attacks leading to emergency visits and/or hospitalizations. For persons with asthma, influenza vaccination may be effective in both reducing influenza infection and asthma attacks.",

keywords = "Asthma, Immunization, Influenza, Laboratory confirmed influenza, Vaccination",

author = "Eleftheria Vasileiou and Aziz Sheikh and Chris Butler and {El Ferkh}, Karim and {Von Wissmann}, Beatrix and Jim McMenamin and Lewis Ritchie and J{\"u}rgen Schwarze and Papadopoulos, {Nikolaos G.} and Johnston, {Sebastian L.} and Lilly Tian and Simpson, {Colin R.}",

note = "The work was funded by the Chief Scientist Office of the Scottish Government under the grant (AUKCAR/14/03). This work is carried out with the support of the Asthma UK Centre for Applied Research (AUK-AC-2012-01).",

year = "2017",

month = oct,

day = "15",

doi = "10.1093/cid/cix524",

language = "English",

volume = "65",

pages = "1388--1395",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Efectiveness of influenza vaccines in Asthma

T2 - A systematic review and meta-analysis

AU - Vasileiou, Eleftheria

AU - Sheikh, Aziz

AU - Butler, Chris

AU - El Ferkh, Karim

AU - Von Wissmann, Beatrix

AU - McMenamin, Jim

AU - Ritchie, Lewis

AU - Schwarze, Jürgen

AU - Papadopoulos, Nikolaos G.

AU - Johnston, Sebastian L.

AU - Tian, Lilly

AU - Simpson, Colin R.

N1 - The work was funded by the Chief Scientist Office of the Scottish Government under the grant (AUKCAR/14/03). This work is carried out with the support of the Asthma UK Centre for Applied Research (AUK-AC-2012-01).

PY - 2017/10/15

Y1 - 2017/10/15

N2 - There is uncertainty about the effectiveness of influenza vaccination in persons with asthma and its impact on asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma. This systematic review and meta-analysis involved searching 12 international databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiological studies (1970-2016). The risk of bias was low for 3 included RCTs. The quality of 3 included observational studies was moderate. The quality of evidence was very low for all study outcomes. Pooled vaccine effectiveness in 1825 persons with asthma from 2 test-negative design case-control studies was 45% (95% confidence interval [CI], 31%-56%) for laboratory-confirmed influenza. Pooled eficacy of live vaccines in reducing influenza was 81% (95% CI, 33%-94%). Live vaccine reduced febrile illness by 72% (95% CI, 20%-90%). Influenza vaccine prevented 59%-78% of asthma attacks leading to emergency visits and/or hospitalizations. For persons with asthma, influenza vaccination may be effective in both reducing influenza infection and asthma attacks.

AB - There is uncertainty about the effectiveness of influenza vaccination in persons with asthma and its impact on asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma. This systematic review and meta-analysis involved searching 12 international databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiological studies (1970-2016). The risk of bias was low for 3 included RCTs. The quality of 3 included observational studies was moderate. The quality of evidence was very low for all study outcomes. Pooled vaccine effectiveness in 1825 persons with asthma from 2 test-negative design case-control studies was 45% (95% confidence interval [CI], 31%-56%) for laboratory-confirmed influenza. Pooled eficacy of live vaccines in reducing influenza was 81% (95% CI, 33%-94%). Live vaccine reduced febrile illness by 72% (95% CI, 20%-90%). Influenza vaccine prevented 59%-78% of asthma attacks leading to emergency visits and/or hospitalizations. For persons with asthma, influenza vaccination may be effective in both reducing influenza infection and asthma attacks.

KW - Asthma

KW - Immunization

KW - Influenza

KW - Laboratory confirmed influenza

KW - Vaccination

UR - http://www.scopus.com/inward/record.url?scp=85032829513&partnerID=8YFLogxK

U2 - 10.1093/cid/cix524

DO - 10.1093/cid/cix524

M3 - Review article

C2 - 28591866

AN - SCOPUS:85032829513

SN - 1058-4838

VL - 65

SP - 1388

EP - 1395

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 8

ER -

Efectiveness of influenza vaccines in Asthma: A systematic review and meta-analysis

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this