Efectiveness of influenza vaccines in Asthma

A systematic review and meta-analysis

Eleftheria Vasileiou* (Corresponding Author), Aziz Sheikh, Chris Butler, Karim El Ferkh, Beatrix Von Wissmann, Jim McMenamin, Lewis Ritchie, Jürgen Schwarze, Nikolaos G. Papadopoulos, Sebastian L. Johnston, Lilly Tian, Colin R. Simpson

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

There is uncertainty about the effectiveness of influenza vaccination in persons with asthma and its impact on asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma. This systematic review and meta-analysis involved searching 12 international databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiological studies (1970-2016). The risk of bias was low for 3 included RCTs. The quality of 3 included observational studies was moderate. The quality of evidence was very low for all study outcomes. Pooled vaccine effectiveness in 1825 persons with asthma from 2 test-negative design case-control studies was 45% (95% confidence interval [CI], 31%-56%) for laboratory-confirmed influenza. Pooled eficacy of live vaccines in reducing influenza was 81% (95% CI, 33%-94%). Live vaccine reduced febrile illness by 72% (95% CI, 20%-90%). Influenza vaccine prevented 59%-78% of asthma attacks leading to emergency visits and/or hospitalizations. For persons with asthma, influenza vaccination may be effective in both reducing influenza infection and asthma attacks.

Original languageEnglish
Pages (from-to)1388-1395
Number of pages8
JournalClinical Infectious Diseases
Volume65
Issue number8
DOIs
Publication statusPublished - 15 Oct 2017

Fingerprint

Influenza Vaccines
Meta-Analysis
Asthma
Human Influenza
Vaccination
Vaccines
Confidence Intervals
Randomized Controlled Trials
Uncertainty
Observational Studies
Case-Control Studies
Epidemiologic Studies
Hospitalization
Emergencies
Fever
Outcome Assessment (Health Care)
Databases
Infection

Keywords

  • Asthma
  • Immunization
  • Influenza
  • Laboratory confirmed influenza
  • Vaccination

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Vasileiou, E., Sheikh, A., Butler, C., El Ferkh, K., Von Wissmann, B., McMenamin, J., ... Simpson, C. R. (2017). Efectiveness of influenza vaccines in Asthma: A systematic review and meta-analysis. Clinical Infectious Diseases, 65(8), 1388-1395. https://doi.org/10.1093/cid/cix524

Efectiveness of influenza vaccines in Asthma : A systematic review and meta-analysis. / Vasileiou, Eleftheria (Corresponding Author); Sheikh, Aziz; Butler, Chris; El Ferkh, Karim; Von Wissmann, Beatrix; McMenamin, Jim; Ritchie, Lewis; Schwarze, Jürgen; Papadopoulos, Nikolaos G.; Johnston, Sebastian L.; Tian, Lilly; Simpson, Colin R.

In: Clinical Infectious Diseases, Vol. 65, No. 8, 15.10.2017, p. 1388-1395.

Research output: Contribution to journalReview article

Vasileiou, E, Sheikh, A, Butler, C, El Ferkh, K, Von Wissmann, B, McMenamin, J, Ritchie, L, Schwarze, J, Papadopoulos, NG, Johnston, SL, Tian, L & Simpson, CR 2017, 'Efectiveness of influenza vaccines in Asthma: A systematic review and meta-analysis', Clinical Infectious Diseases, vol. 65, no. 8, pp. 1388-1395. https://doi.org/10.1093/cid/cix524
Vasileiou E, Sheikh A, Butler C, El Ferkh K, Von Wissmann B, McMenamin J et al. Efectiveness of influenza vaccines in Asthma: A systematic review and meta-analysis. Clinical Infectious Diseases. 2017 Oct 15;65(8):1388-1395. https://doi.org/10.1093/cid/cix524
Vasileiou, Eleftheria ; Sheikh, Aziz ; Butler, Chris ; El Ferkh, Karim ; Von Wissmann, Beatrix ; McMenamin, Jim ; Ritchie, Lewis ; Schwarze, Jürgen ; Papadopoulos, Nikolaos G. ; Johnston, Sebastian L. ; Tian, Lilly ; Simpson, Colin R. / Efectiveness of influenza vaccines in Asthma : A systematic review and meta-analysis. In: Clinical Infectious Diseases. 2017 ; Vol. 65, No. 8. pp. 1388-1395.
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abstract = "There is uncertainty about the effectiveness of influenza vaccination in persons with asthma and its impact on asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma. This systematic review and meta-analysis involved searching 12 international databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiological studies (1970-2016). The risk of bias was low for 3 included RCTs. The quality of 3 included observational studies was moderate. The quality of evidence was very low for all study outcomes. Pooled vaccine effectiveness in 1825 persons with asthma from 2 test-negative design case-control studies was 45{\%} (95{\%} confidence interval [CI], 31{\%}-56{\%}) for laboratory-confirmed influenza. Pooled eficacy of live vaccines in reducing influenza was 81{\%} (95{\%} CI, 33{\%}-94{\%}). Live vaccine reduced febrile illness by 72{\%} (95{\%} CI, 20{\%}-90{\%}). Influenza vaccine prevented 59{\%}-78{\%} of asthma attacks leading to emergency visits and/or hospitalizations. For persons with asthma, influenza vaccination may be effective in both reducing influenza infection and asthma attacks.",
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