細胞診と自己採取ヒトパピローマウイルス検査を選べることの効果: 北海道での子宮頸がん検診未受診者対策の成績

Translated title of the contribution: Effect of choosing between cytological examination and self-collecting human papillomavirus test: results of measures for those who have not undergone cervical cancer screening in Hokkaido

Shinobu Taniguchi, Noriaki Sakuragi, Sharon J. B. Hanley, Kizuna Tsukiyama, Hiromasa Fujita, Satoru Sagae, Naofumi Kajii, Hidemichi Watari, Akiko Tamakoshi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives We investigated the participation and detection rates of cervical lesions in cervical screening non-attenders offered HPV (human papillomavirus) self-sampling with cytology triage.Methods From 2016 to 2018, HPV self-sampling was routinely offered as an option, along with cytology, to all non-attenders in Ebetsu City, Japan. The primary endpoints were ≥CIN2 and ≥CIN3 detection rates, and secondary endpoints were abnormal cytology rates and follow-up compliance.Results Overall, recall invitations were mailed to 6,116 non-attenders, with a response rate of 15.9% (cytology: 6.5%, HPV testing: 9.4%). Of the responders to undergo HPV self-sampling, 11.7% had a positive result and were referred to cytology triage. Moreover, ≥CIN2 and ≥CIN3 detection rates were 1.7% and 0.9%, respectively, in the HPV self-sampling group, and 1.0% and 0.8%, respectively, in the cytology group, showing no statistically significant differences. In those who underwent cytology triage following an HPV positive test, ≥CIN2 and ≥CIN3 detection rates were 23.8% and 11.9%, respectively, which was significantly higher than those who only underwent cytology alone.Conclusion HPV self-sampling followed by cytology triage is highly effective at detecting high grade disease in non-attenders. Thus, multi-municipality-based studies to standardize processes involving this method are warranted. Furthermore, HPV self-sampling could be a promising method for inviting non-attenders who have difficulty undergoing cervical screening in the COVID-19 pandemic era.
Translated title of the contributionEffect of choosing between cytological examination and self-collecting human papillomavirus test: results of measures for those who have not undergone cervical cancer screening in Hokkaido
Original languageOther
Pages (from-to)719-727
Number of pages9
JournalNihon Koshu Eisei Zasshi
Volume68
Issue number11
Early online date8 Jun 2021
DOIs
Publication statusPublished - 15 Nov 2021

Keywords

  • Female
  • Humans
  • *COVID-19
  • SARS-CoV-2
  • Early Detection of Cancer
  • Mass Screening
  • *Papillomavirus Infections/diagnosis
  • *Uterine Cervical Neoplasms/diagnosis
  • Triage
  • *Uterine Cervical Dysplasia/diagnosis
  • cervical screening
  • Feasibility Studies
  • feasibility study
  • HPV test
  • non-attender
  • Pandemics
  • recall
  • self-sampling

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