Effect of CLA supplementation on immune function in young healthy volunteers

H J Song, I Grant, D Rotondo, I Mohede, N Sattar, S D Heys, K W J Wahle

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123 Citations (Scopus)

Abstract

Objectives: This study investigated the effect of dietary CLA supplementation (3g/day; 50: 50 mix of the two major isomers) on the immune system and plasma lipids and glucose of healthy human ( male and female) volunteers.

Design: Double-blind, randomized, reference-controlled study.

Subject and intervention: A total of 28 healthy male and female participants aged 25-50y received either high oleic sunflower oil ( reference) or 50% CLA 9-11 and 50% CLA 10-12 CLA isomers (50:50 CLA-triglyceride form). The treatments were given as supplements in soft-gel capsules providing a total 3 g (6 x 500 mg capsules) per day in treatment groups for 12 weeks. A 12-week washout period followed the intervention period.

Results: Levels of plasma IgA and IgM were increased (P<0.05 and 0.01 respectively), while plasma IgE levels were decreased (P<0.05). CLA supplementation also decreased the levels of the proinflammatory cytokines, TNF-alpha and IL-1 beta (P<0.05), but increased the levels of the anti-inflammatory cytokine, IL-10 (P<0.05). Another aspect of immune function, delayed type hypersensitivity (DTH) response, was decreased during and after CLA supplementation (P<0.05). However, plasma glucose, lipids, lymphocyte phenotypic results were not affected significantly by CLA.

Conclusion: This is the first study to show that CLA, a fatty acid naturally found in dairy and meat products, can beneficially affect immune function in healthy human volunteers.

Sponsorship: This study was supported by Loders-Croklaan, The Netherlands and SEERAD ( Scottish Executive Environmental Rural and Agriculture Department).

Original languageEnglish
Pages (from-to)508-517
Number of pages10
JournalEuropean Journal of Clinical Nutrition
Volume59
DOIs
Publication statusPublished - 2005

Keywords

  • conjugated linoleic acid (CLA)
  • immune function
  • fatty acids
  • human
  • CONJUGATED LINOLEIC-ACID
  • POLYUNSATURATED FATTY-ACIDS
  • CORONARY-HEART-DISEASE
  • C-REACTIVE PROTEIN
  • CYTOKINE PRODUCTION
  • DIETARY SUPPLEMENTATION
  • ADIPOSE-TISSUE
  • SCID MICE
  • MILK-FAT
  • SUPPRESSES

Cite this

Song, H. J., Grant, I., Rotondo, D., Mohede, I., Sattar, N., Heys, S. D., & Wahle, K. W. J. (2005). Effect of CLA supplementation on immune function in young healthy volunteers. European Journal of Clinical Nutrition, 59, 508-517. https://doi.org/10.1038/sj.ejcn.1602102