Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh

SMZ Hyder , Farhana Haseen, M Rahman, Mélody C. Tondeur, S Zlotkin

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background. The effectiveness of commonly suggested public health interventions to control childhood iron-deficiency anemia has been low.Objective. To determine whether iron provided in Sprinkles daily or in a higher dose once weekly affected hemoglobin, serum ferritin levels, and serum transferrin receptor levels, and to determine whether there were differences in the effects of the two regimens.Methods. In this cluster- randomized, community-based trial conducted in rural areas of Bangladesh, 136 children aged 12 to 24 months with mild to moderate anemia (hemoglobin 70-109 g/L) were randomly allocated to receive Sprinkles daily (12.5 mg of elemental iron, n = 79) or once weekly (30 mg of elemental iron, n = 73) for 8 weeks. Hemoglobin, serum ferritin, and serum transferrin receptor were assessed at the start and end of the intervention.Results. In both groups, there were significant increases in hemoglobin and serum ferritin and a significant decrease in serum transferrin receptor (p <.01). There were no significant differences between the groups in the increases in hemoglobin (16.1 +/- 13.2 g/L for the group receiving Sprinkles daily and 12.3 +/- 13.3 g/L for the group receiving Sprinkles once weekly) and serum ferritin (10. 6 and 5.7 mu g/L, respectively). The decrease in serum transferrin receptor also did not significantly differ between the groups (median, -2.5 and - 1. 8 mg/L, respectively). The prevalence rates of iron-deficiency anemia, depleted iron stores, and tissue iron deficiency decreased significantly within each group (p <.01), with no significant differences between the groups.Conclusions. Home fortification of complementary foods with Sprinkles given either daily or once weekly improved iron-deficiency anemia and iron status among young children.
Original languageEnglish
Pages (from-to)156-164
Number of pages9
JournalFood & Nutrition Bulletin
Volume28
Issue number2
Publication statusPublished - 2007

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Bangladesh
Micronutrients
hemoglobin
dietary minerals
Hemoglobins
Iron
serum
trace element
ferritin
transferrin
iron
iron deficiency anemia
Transferrin Receptors
anemia
Ferritins
Serum
Iron-Deficiency Anemias
receptors
Group
complementary foods

Keywords

  • Bangladesh
  • children
  • daily
  • iron
  • iron-deficiency anemia
  • Sprinkles
  • weekly

Cite this

Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh. / Hyder , SMZ; Haseen, Farhana; Rahman, M; Tondeur, Mélody C.; Zlotkin , S.

In: Food & Nutrition Bulletin, Vol. 28, No. 2, 2007, p. 156-164 .

Research output: Contribution to journalArticle

Hyder , SMZ ; Haseen, Farhana ; Rahman, M ; Tondeur, Mélody C. ; Zlotkin , S. / Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh. In: Food & Nutrition Bulletin. 2007 ; Vol. 28, No. 2. pp. 156-164 .
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abstract = "Background. The effectiveness of commonly suggested public health interventions to control childhood iron-deficiency anemia has been low.Objective. To determine whether iron provided in Sprinkles daily or in a higher dose once weekly affected hemoglobin, serum ferritin levels, and serum transferrin receptor levels, and to determine whether there were differences in the effects of the two regimens.Methods. In this cluster- randomized, community-based trial conducted in rural areas of Bangladesh, 136 children aged 12 to 24 months with mild to moderate anemia (hemoglobin 70-109 g/L) were randomly allocated to receive Sprinkles daily (12.5 mg of elemental iron, n = 79) or once weekly (30 mg of elemental iron, n = 73) for 8 weeks. Hemoglobin, serum ferritin, and serum transferrin receptor were assessed at the start and end of the intervention.Results. In both groups, there were significant increases in hemoglobin and serum ferritin and a significant decrease in serum transferrin receptor (p <.01). There were no significant differences between the groups in the increases in hemoglobin (16.1 +/- 13.2 g/L for the group receiving Sprinkles daily and 12.3 +/- 13.3 g/L for the group receiving Sprinkles once weekly) and serum ferritin (10. 6 and 5.7 mu g/L, respectively). The decrease in serum transferrin receptor also did not significantly differ between the groups (median, -2.5 and - 1. 8 mg/L, respectively). The prevalence rates of iron-deficiency anemia, depleted iron stores, and tissue iron deficiency decreased significantly within each group (p <.01), with no significant differences between the groups.Conclusions. Home fortification of complementary foods with Sprinkles given either daily or once weekly improved iron-deficiency anemia and iron status among young children.",
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T1 - Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh

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AU - Haseen, Farhana

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AU - Tondeur, Mélody C.

AU - Zlotkin , S

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N2 - Background. The effectiveness of commonly suggested public health interventions to control childhood iron-deficiency anemia has been low.Objective. To determine whether iron provided in Sprinkles daily or in a higher dose once weekly affected hemoglobin, serum ferritin levels, and serum transferrin receptor levels, and to determine whether there were differences in the effects of the two regimens.Methods. In this cluster- randomized, community-based trial conducted in rural areas of Bangladesh, 136 children aged 12 to 24 months with mild to moderate anemia (hemoglobin 70-109 g/L) were randomly allocated to receive Sprinkles daily (12.5 mg of elemental iron, n = 79) or once weekly (30 mg of elemental iron, n = 73) for 8 weeks. Hemoglobin, serum ferritin, and serum transferrin receptor were assessed at the start and end of the intervention.Results. In both groups, there were significant increases in hemoglobin and serum ferritin and a significant decrease in serum transferrin receptor (p <.01). There were no significant differences between the groups in the increases in hemoglobin (16.1 +/- 13.2 g/L for the group receiving Sprinkles daily and 12.3 +/- 13.3 g/L for the group receiving Sprinkles once weekly) and serum ferritin (10. 6 and 5.7 mu g/L, respectively). The decrease in serum transferrin receptor also did not significantly differ between the groups (median, -2.5 and - 1. 8 mg/L, respectively). The prevalence rates of iron-deficiency anemia, depleted iron stores, and tissue iron deficiency decreased significantly within each group (p <.01), with no significant differences between the groups.Conclusions. Home fortification of complementary foods with Sprinkles given either daily or once weekly improved iron-deficiency anemia and iron status among young children.

AB - Background. The effectiveness of commonly suggested public health interventions to control childhood iron-deficiency anemia has been low.Objective. To determine whether iron provided in Sprinkles daily or in a higher dose once weekly affected hemoglobin, serum ferritin levels, and serum transferrin receptor levels, and to determine whether there were differences in the effects of the two regimens.Methods. In this cluster- randomized, community-based trial conducted in rural areas of Bangladesh, 136 children aged 12 to 24 months with mild to moderate anemia (hemoglobin 70-109 g/L) were randomly allocated to receive Sprinkles daily (12.5 mg of elemental iron, n = 79) or once weekly (30 mg of elemental iron, n = 73) for 8 weeks. Hemoglobin, serum ferritin, and serum transferrin receptor were assessed at the start and end of the intervention.Results. In both groups, there were significant increases in hemoglobin and serum ferritin and a significant decrease in serum transferrin receptor (p <.01). There were no significant differences between the groups in the increases in hemoglobin (16.1 +/- 13.2 g/L for the group receiving Sprinkles daily and 12.3 +/- 13.3 g/L for the group receiving Sprinkles once weekly) and serum ferritin (10. 6 and 5.7 mu g/L, respectively). The decrease in serum transferrin receptor also did not significantly differ between the groups (median, -2.5 and - 1. 8 mg/L, respectively). The prevalence rates of iron-deficiency anemia, depleted iron stores, and tissue iron deficiency decreased significantly within each group (p <.01), with no significant differences between the groups.Conclusions. Home fortification of complementary foods with Sprinkles given either daily or once weekly improved iron-deficiency anemia and iron status among young children.

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JO - Food & Nutrition Bulletin

JF - Food & Nutrition Bulletin

SN - 0379-5721

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