EFFECT OF DELTA(9)-TETRAHYDROCANNABINOL ON CIRCLING IN RATS INDUCED BY INTRANIGRAL MUSCIMOL ADMINISTRATION

A P WICKENS, Roger Guy Pertwee

Research output: Contribution to journalComment/debate

14 Citations (Scopus)

Abstract

Unilateral injection of 25 ng of muscimol into the rat substantia nigra pars reticulata induced contralateral circling. Circling induced by 25 ng of muscimol was increased by simultaneous administration of 1 mu g of Delta(9)-tetrahydrocannabinol and abolished by 10 mu g. Previous experiments have shown that Delta(9)-tetrahydrocannabinol enhances muscimol-induced catalepsy in the globus pallidus. These results identify another brain area in which synergism between Delta(9)-tetrahydrocannabinol and muscimol can occur and show that Delta(9)-tetrahydrocannabinol can enhance an excitatory as well as an inhibitory GABAergic motor effect. The data support the hypothesis that cannabinoids can facilitate transmission along central gamma-aminobutyric acid (GABA) releasing pathways.

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalEuropean Journal of Pharmacology
Volume282
Issue number1-3
DOIs
Publication statusPublished - 25 Aug 1995

Keywords

  • MUSCIMOL
  • DELTA(9)-TETRAHYDROCANNABINOL
  • SUBSTANTIA NIGRA, PARS RETICULATA
  • CIRCLING BEHAVIOR
  • CONTRALATERAL CIRCLING
  • DRUG INTERACTION
  • NEUROTRANSMITTER UPTAKE
  • BRAIN SYNAPTOSOMES
  • SUBSTANTIA NIGRA
  • BASAL GANGLIA
  • CANNABINOIDS
  • LOCALIZATION
  • RECEPTORS
  • BEHAVIOR
  • RELEASE
  • Muscimol
  • ¿9-Tetrahydrocannabinol
  • Substantia nigra
  • pars reticulata
  • Circling behavior
  • Contralateral circling
  • Drug interaction

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