EFFECT OF DELTA(9)-TETRAHYDROCANNABINOL ON CIRCLING IN RATS INDUCED BY INTRANIGRAL MUSCIMOL ADMINISTRATION

A P  WICKENS; Roger Guy Pertwee

doi:10.1016/0014-2999(95)00346-M

EFFECT OF DELTA(9)-TETRAHYDROCANNABINOL ON CIRCLING IN RATS INDUCED BY INTRANIGRAL MUSCIMOL ADMINISTRATION

A P WICKENS, Roger Guy Pertwee

Medical Sciences

Research output: Contribution to journal › Comment/debate › peer-review

14 Citations (Scopus)

Abstract

Unilateral injection of 25 ng of muscimol into the rat substantia nigra pars reticulata induced contralateral circling. Circling induced by 25 ng of muscimol was increased by simultaneous administration of 1 mu g of Delta(9)-tetrahydrocannabinol and abolished by 10 mu g. Previous experiments have shown that Delta(9)-tetrahydrocannabinol enhances muscimol-induced catalepsy in the globus pallidus. These results identify another brain area in which synergism between Delta(9)-tetrahydrocannabinol and muscimol can occur and show that Delta(9)-tetrahydrocannabinol can enhance an excitatory as well as an inhibitory GABAergic motor effect. The data support the hypothesis that cannabinoids can facilitate transmission along central gamma-aminobutyric acid (GABA) releasing pathways.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	European Journal of Pharmacology
Volume	282
Issue number	1-3
DOIs	https://doi.org/10.1016/0014-2999(95)00346-M
Publication status	Published - 25 Aug 1995

Keywords

MUSCIMOL
DELTA(9)-TETRAHYDROCANNABINOL
SUBSTANTIA NIGRA, PARS RETICULATA
CIRCLING BEHAVIOR
CONTRALATERAL CIRCLING
DRUG INTERACTION
NEUROTRANSMITTER UPTAKE
BRAIN SYNAPTOSOMES
SUBSTANTIA NIGRA
BASAL GANGLIA
CANNABINOIDS
LOCALIZATION
RECEPTORS
BEHAVIOR
RELEASE
Muscimol
¿9-Tetrahydrocannabinol
Substantia nigra
pars reticulata
Circling behavior
Contralateral circling
Drug interaction

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@article{f5c3eb9e34294771ab496dcf920aef5b,

title = "EFFECT OF DELTA(9)-TETRAHYDROCANNABINOL ON CIRCLING IN RATS INDUCED BY INTRANIGRAL MUSCIMOL ADMINISTRATION",

abstract = "Unilateral injection of 25 ng of muscimol into the rat substantia nigra pars reticulata induced contralateral circling. Circling induced by 25 ng of muscimol was increased by simultaneous administration of 1 mu g of Delta(9)-tetrahydrocannabinol and abolished by 10 mu g. Previous experiments have shown that Delta(9)-tetrahydrocannabinol enhances muscimol-induced catalepsy in the globus pallidus. These results identify another brain area in which synergism between Delta(9)-tetrahydrocannabinol and muscimol can occur and show that Delta(9)-tetrahydrocannabinol can enhance an excitatory as well as an inhibitory GABAergic motor effect. The data support the hypothesis that cannabinoids can facilitate transmission along central gamma-aminobutyric acid (GABA) releasing pathways.",

keywords = "MUSCIMOL, DELTA(9)-TETRAHYDROCANNABINOL, SUBSTANTIA NIGRA, PARS RETICULATA, CIRCLING BEHAVIOR, CONTRALATERAL CIRCLING, DRUG INTERACTION, NEUROTRANSMITTER UPTAKE, BRAIN SYNAPTOSOMES, SUBSTANTIA NIGRA, BASAL GANGLIA, CANNABINOIDS, LOCALIZATION, RECEPTORS, BEHAVIOR, RELEASE, Muscimol, ¿9-Tetrahydrocannabinol, Substantia nigra, pars reticulata, Circling behavior, Contralateral circling, Drug interaction",

author = "WICKENS, {A P} and Pertwee, {Roger Guy}",

year = "1995",

month = aug,

day = "25",

doi = "10.1016/0014-2999(95)00346-M",

language = "English",

volume = "282",

pages = "251--254",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1-3",

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TY - JOUR

T1 - EFFECT OF DELTA(9)-TETRAHYDROCANNABINOL ON CIRCLING IN RATS INDUCED BY INTRANIGRAL MUSCIMOL ADMINISTRATION

AU - WICKENS, A P

AU - Pertwee, Roger Guy

PY - 1995/8/25

Y1 - 1995/8/25

N2 - Unilateral injection of 25 ng of muscimol into the rat substantia nigra pars reticulata induced contralateral circling. Circling induced by 25 ng of muscimol was increased by simultaneous administration of 1 mu g of Delta(9)-tetrahydrocannabinol and abolished by 10 mu g. Previous experiments have shown that Delta(9)-tetrahydrocannabinol enhances muscimol-induced catalepsy in the globus pallidus. These results identify another brain area in which synergism between Delta(9)-tetrahydrocannabinol and muscimol can occur and show that Delta(9)-tetrahydrocannabinol can enhance an excitatory as well as an inhibitory GABAergic motor effect. The data support the hypothesis that cannabinoids can facilitate transmission along central gamma-aminobutyric acid (GABA) releasing pathways.

AB - Unilateral injection of 25 ng of muscimol into the rat substantia nigra pars reticulata induced contralateral circling. Circling induced by 25 ng of muscimol was increased by simultaneous administration of 1 mu g of Delta(9)-tetrahydrocannabinol and abolished by 10 mu g. Previous experiments have shown that Delta(9)-tetrahydrocannabinol enhances muscimol-induced catalepsy in the globus pallidus. These results identify another brain area in which synergism between Delta(9)-tetrahydrocannabinol and muscimol can occur and show that Delta(9)-tetrahydrocannabinol can enhance an excitatory as well as an inhibitory GABAergic motor effect. The data support the hypothesis that cannabinoids can facilitate transmission along central gamma-aminobutyric acid (GABA) releasing pathways.

KW - MUSCIMOL

KW - DELTA(9)-TETRAHYDROCANNABINOL

KW - SUBSTANTIA NIGRA, PARS RETICULATA

KW - CIRCLING BEHAVIOR

KW - CONTRALATERAL CIRCLING

KW - DRUG INTERACTION

KW - NEUROTRANSMITTER UPTAKE

KW - BRAIN SYNAPTOSOMES

KW - SUBSTANTIA NIGRA

KW - BASAL GANGLIA

KW - CANNABINOIDS

KW - LOCALIZATION

KW - RECEPTORS

KW - BEHAVIOR

KW - RELEASE

KW - Muscimol

KW - ¿9-Tetrahydrocannabinol

KW - Substantia nigra

KW - pars reticulata

KW - Circling behavior

KW - Contralateral circling

KW - Drug interaction

U2 - 10.1016/0014-2999(95)00346-M

DO - 10.1016/0014-2999(95)00346-M

M3 - Comment/debate

VL - 282

SP - 251

EP - 254

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-3

ER -

EFFECT OF DELTA(9)-TETRAHYDROCANNABINOL ON CIRCLING IN RATS INDUCED BY INTRANIGRAL MUSCIMOL ADMINISTRATION

Abstract

Keywords

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