Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation

Francesca Borrelli, Francesco Capasso, Raffaele Capasso, Valeria Ascione, Gabriella Aviello, Rocco Longo, Angelo A Izzo

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride. The inhibitory effect of BSE on acetylcholine-induced contractions was reduced by the L-type Ca(2+) channel blockers verapamil and nifedipine, but not by the sarcoplasmic reticulum Ca(2+)-ATPase inhibitor cyclopiazonic acid, by the phosphodiesterase type IV inhibitor rolipram or by the lipoxygenase inhibitor zileuton. 3-acetyl-11-keto-beta-boswellic acid, one of the main active ingredients of B. serrata, inhibited acetylcholine-induced contractions. BSE inhibited upper gastrointestinal transit in croton oil-treated mice as well as castor oil-induced diarrhoea. However, BSE did not affect intestinal motility in control mice, both in the small and in the large intestine. It is concluded that BSE directly inhibits intestinal motility with a mechanism involving L-type Ca(2+) channels. BSE prevents diarrhoea and normalizes intestinal motility in pathophysiological states without slowing the rate of transit in control animals. These results could explain, at least in part, the clinical efficacy of this Ayurvedic remedy in reducing diarrhoea in patients with inflammatory bowel disease.

Original languageEnglish
Pages (from-to)553-60
Number of pages8
JournalBritish Journal of Pharmacology
Volume148
Issue number4
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Boswellia
Gastrointestinal Motility
Constipation
Diarrhea
Rodentia
Acetylcholine
Inflammatory Bowel Diseases
zileuton
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Croton Oil
Type 4 Cyclic Nucleotide Phosphodiesterase
Gastrointestinal Transit
Rolipram
Castor Oil
Lipoxygenase Inhibitors
Phosphodiesterase Inhibitors
Large Intestine
Nifedipine
Verapamil
Ileum

Keywords

  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Animals
  • Boswellia
  • Calcium
  • Calcium Channels, L-Type
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Diarrhea
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Gastrointestinal Motility
  • Gastrointestinal Transit
  • Guinea Pigs
  • Inflammatory Bowel Diseases
  • Male
  • Mice
  • Mice, Inbred ICR
  • Phytotherapy
  • Plant Extracts
  • Journal Article

Cite this

Borrelli, F., Capasso, F., Capasso, R., Ascione, V., Aviello, G., Longo, R., & Izzo, A. A. (2006). Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation. British Journal of Pharmacology, 148(4), 553-60. https://doi.org/10.1038/sj.bjp.0706740

Effect of Boswellia serrata on intestinal motility in rodents : inhibition of diarrhoea without constipation. / Borrelli, Francesca; Capasso, Francesco; Capasso, Raffaele; Ascione, Valeria; Aviello, Gabriella; Longo, Rocco; Izzo, Angelo A.

In: British Journal of Pharmacology, Vol. 148, No. 4, 06.2006, p. 553-60.

Research output: Contribution to journalArticle

Borrelli, F, Capasso, F, Capasso, R, Ascione, V, Aviello, G, Longo, R & Izzo, AA 2006, 'Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation', British Journal of Pharmacology, vol. 148, no. 4, pp. 553-60. https://doi.org/10.1038/sj.bjp.0706740
Borrelli, Francesca ; Capasso, Francesco ; Capasso, Raffaele ; Ascione, Valeria ; Aviello, Gabriella ; Longo, Rocco ; Izzo, Angelo A. / Effect of Boswellia serrata on intestinal motility in rodents : inhibition of diarrhoea without constipation. In: British Journal of Pharmacology. 2006 ; Vol. 148, No. 4. pp. 553-60.
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KW - Mice

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KW - Phytotherapy

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