Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial

Alison Avenell, Marion Kay Campbell, Jonathan Alistair Cook, Philip Christopher Hannaford, Mary Mueni Kilonzo, Geraldine McNeill, Anne Catherine Milne, Craig R Ramsay, David Gwyn Seymour, Audrey Isabella Stephen, Luke David Vale, Writing Group on the MAVIS trial

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.

Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.

Setting Communities associated with six general practices in Grampian, Scotland.

Participants 910 men and women aged 65 or over who did not take vitamins or minerals.

Interventions Daily multivitamin and multimineral supplementation or placebo for one year.

Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.

Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.

Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.

Original languageEnglish
Pages (from-to)324-329
Number of pages5
JournalBritish Medical Journal
Volume331
Issue number7512
DOIs
Publication statusPublished - Aug 2005

Keywords

  • RESPIRATORY-TRACT INFECTIONS
  • ELDERLY SUBJECTS
  • IMMUNE-RESPONSES
  • VITAMIN-E
  • IMPACT

Cite this

Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial. / Avenell, Alison; Campbell, Marion Kay; Cook, Jonathan Alistair; Hannaford, Philip Christopher; Kilonzo, Mary Mueni; McNeill, Geraldine; Milne, Anne Catherine; Ramsay, Craig R; Seymour, David Gwyn; Stephen, Audrey Isabella; Vale, Luke David; Writing Group on the MAVIS trial.

In: British Medical Journal, Vol. 331, No. 7512, 08.2005, p. 324-329.

Research output: Contribution to journalArticle

@article{aef4919cfce148989345be90ac064cd2,
title = "Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial",
abstract = "Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.Setting Communities associated with six general practices in Grampian, Scotland.Participants 910 men and women aged 65 or over who did not take vitamins or minerals.Interventions Daily multivitamin and multimineral supplementation or placebo for one year.Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95{\%} confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.",
keywords = "RESPIRATORY-TRACT INFECTIONS, ELDERLY SUBJECTS, IMMUNE-RESPONSES, VITAMIN-E, IMPACT",
author = "Alison Avenell and Campbell, {Marion Kay} and Cook, {Jonathan Alistair} and Hannaford, {Philip Christopher} and Kilonzo, {Mary Mueni} and Geraldine McNeill and Milne, {Anne Catherine} and Ramsay, {Craig R} and Seymour, {David Gwyn} and Stephen, {Audrey Isabella} and Vale, {Luke David} and {Writing Group on the MAVIS trial}",
year = "2005",
month = "8",
doi = "10.1136/bmj.331.7512.324",
language = "English",
volume = "331",
pages = "324--329",
journal = "BMJ",
issn = "0959-8146",
publisher = "BMJ Publishing Group",
number = "7512",

}

TY - JOUR

T1 - Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial

AU - Avenell, Alison

AU - Campbell, Marion Kay

AU - Cook, Jonathan Alistair

AU - Hannaford, Philip Christopher

AU - Kilonzo, Mary Mueni

AU - McNeill, Geraldine

AU - Milne, Anne Catherine

AU - Ramsay, Craig R

AU - Seymour, David Gwyn

AU - Stephen, Audrey Isabella

AU - Vale, Luke David

AU - Writing Group on the MAVIS trial

PY - 2005/8

Y1 - 2005/8

N2 - Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.Setting Communities associated with six general practices in Grampian, Scotland.Participants 910 men and women aged 65 or over who did not take vitamins or minerals.Interventions Daily multivitamin and multimineral supplementation or placebo for one year.Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.

AB - Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.Setting Communities associated with six general practices in Grampian, Scotland.Participants 910 men and women aged 65 or over who did not take vitamins or minerals.Interventions Daily multivitamin and multimineral supplementation or placebo for one year.Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.

KW - RESPIRATORY-TRACT INFECTIONS

KW - ELDERLY SUBJECTS

KW - IMMUNE-RESPONSES

KW - VITAMIN-E

KW - IMPACT

U2 - 10.1136/bmj.331.7512.324

DO - 10.1136/bmj.331.7512.324

M3 - Article

VL - 331

SP - 324

EP - 329

JO - BMJ

JF - BMJ

SN - 0959-8146

IS - 7512

ER -