Abstract
Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.
Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.
Setting Communities associated with six general practices in Grampian, Scotland.
Participants 910 men and women aged 65 or over who did not take vitamins or minerals.
Interventions Daily multivitamin and multimineral supplementation or placebo for one year.
Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.
Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.
Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.
| Original language | English |
|---|---|
| Pages (from-to) | 324-329 |
| Number of pages | 5 |
| Journal | British Medical Journal |
| Volume | 331 |
| Issue number | 7512 |
| DOIs | |
| Publication status | Published - Aug 2005 |
Keywords
- RESPIRATORY-TRACT INFECTIONS
- ELDERLY SUBJECTS
- IMMUNE-RESPONSES
- VITAMIN-E
- IMPACT
Cite this
Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial. / Avenell, Alison; Campbell, Marion Kay; Cook, Jonathan Alistair; Hannaford, Philip Christopher; Kilonzo, Mary Mueni; McNeill, Geraldine; Milne, Anne Catherine; Ramsay, Craig R; Seymour, David Gwyn; Stephen, Audrey Isabella; Vale, Luke David; Writing Group on the MAVIS trial.
In: British Medical Journal, Vol. 331, No. 7512, 08.2005, p. 324-329.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial
AU - Avenell, Alison
AU - Campbell, Marion Kay
AU - Cook, Jonathan Alistair
AU - Hannaford, Philip Christopher
AU - Kilonzo, Mary Mueni
AU - McNeill, Geraldine
AU - Milne, Anne Catherine
AU - Ramsay, Craig R
AU - Seymour, David Gwyn
AU - Stephen, Audrey Isabella
AU - Vale, Luke David
AU - Writing Group on the MAVIS trial
PY - 2005/8
Y1 - 2005/8
N2 - Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.Setting Communities associated with six general practices in Grampian, Scotland.Participants 910 men and women aged 65 or over who did not take vitamins or minerals.Interventions Daily multivitamin and multimineral supplementation or placebo for one year.Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.
AB - Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.Setting Communities associated with six general practices in Grampian, Scotland.Participants 910 men and women aged 65 or over who did not take vitamins or minerals.Interventions Daily multivitamin and multimineral supplementation or placebo for one year.Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.
KW - RESPIRATORY-TRACT INFECTIONS
KW - ELDERLY SUBJECTS
KW - IMMUNE-RESPONSES
KW - VITAMIN-E
KW - IMPACT
U2 - 10.1136/bmj.331.7512.324
DO - 10.1136/bmj.331.7512.324
M3 - Article
VL - 331
SP - 324
EP - 329
JO - BMJ
JF - BMJ
SN - 0959-8146
IS - 7512
ER -