Effect of Phytohemagglutinin on the Growth of Krebs-II Tumor-Cells, Body Metabolism and Internal Organs of Mice

S BARDOCZ, George Grant, A PUSZTAI, T J DUGUID, David Stanley Brown, I F PRYME

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Abstract

Neoplastic proliferation requires the availability of polyamines. Phytohaemagglutinin (PHA) is a potent growth factor which induces polyamine-dependent growth of the gut. In the hope of directing polyamines and other nutrients away from the tumour to the growing gut, mice fed PHA-containing or lactalbumin diets were injected intraperitoneally with Krebs II ascites cells and the number of tumour cells and the weights of internal organs were followed. PHA-treatment significantly slowed down the proliferation of tumour cells. Changes in the weight and polyamine content of tissues indicated that inter-organ competition between the tumour and vital organs can be used to manipulate the metabolism of tumour-bearing mice.

Original languageEnglish
Pages (from-to)1369-1374
Number of pages6
JournalInternational Journal of Oncology
Volume5
Issue number6
Publication statusPublished - Dec 1994

Keywords

  • phytohemagglutinin
  • gut
  • growth factors
  • polyamines
  • lipids
  • mice
  • small-intestine
  • tissues
  • protein
  • lectin
  • rat

Cite this

BARDOCZ, S., Grant, G., PUSZTAI, A., DUGUID, T. J., Brown, D. S., & PRYME, I. F. (1994). Effect of Phytohemagglutinin on the Growth of Krebs-II Tumor-Cells, Body Metabolism and Internal Organs of Mice. International Journal of Oncology, 5(6), 1369-1374.