Effect of Phytohemagglutinin on the Growth of Krebs-II Tumor-Cells, Body Metabolism and Internal Organs of Mice

S BARDOCZ, George Grant, A PUSZTAI, T J DUGUID, David Stanley Brown, I F PRYME

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Neoplastic proliferation requires the availability of polyamines. Phytohaemagglutinin (PHA) is a potent growth factor which induces polyamine-dependent growth of the gut. In the hope of directing polyamines and other nutrients away from the tumour to the growing gut, mice fed PHA-containing or lactalbumin diets were injected intraperitoneally with Krebs II ascites cells and the number of tumour cells and the weights of internal organs were followed. PHA-treatment significantly slowed down the proliferation of tumour cells. Changes in the weight and polyamine content of tissues indicated that inter-organ competition between the tumour and vital organs can be used to manipulate the metabolism of tumour-bearing mice.

Original languageEnglish
Pages (from-to)1369-1374
Number of pages6
JournalInternational Journal of Oncology
Volume5
Issue number6
Publication statusPublished - Dec 1994

Keywords

  • phytohemagglutinin
  • gut
  • growth factors
  • polyamines
  • lipids
  • mice
  • small-intestine
  • tissues
  • protein
  • lectin
  • rat

Cite this

BARDOCZ, S., Grant, G., PUSZTAI, A., DUGUID, T. J., Brown, D. S., & PRYME, I. F. (1994). Effect of Phytohemagglutinin on the Growth of Krebs-II Tumor-Cells, Body Metabolism and Internal Organs of Mice. International Journal of Oncology, 5(6), 1369-1374.

Effect of Phytohemagglutinin on the Growth of Krebs-II Tumor-Cells, Body Metabolism and Internal Organs of Mice. / BARDOCZ, S ; Grant, George; PUSZTAI, A ; DUGUID, T J ; Brown, David Stanley; PRYME, I F .

In: International Journal of Oncology, Vol. 5, No. 6, 12.1994, p. 1369-1374.

Research output: Contribution to journalArticle

BARDOCZ, S, Grant, G, PUSZTAI, A, DUGUID, TJ, Brown, DS & PRYME, IF 1994, 'Effect of Phytohemagglutinin on the Growth of Krebs-II Tumor-Cells, Body Metabolism and Internal Organs of Mice', International Journal of Oncology, vol. 5, no. 6, pp. 1369-1374.
BARDOCZ, S ; Grant, George ; PUSZTAI, A ; DUGUID, T J ; Brown, David Stanley ; PRYME, I F . / Effect of Phytohemagglutinin on the Growth of Krebs-II Tumor-Cells, Body Metabolism and Internal Organs of Mice. In: International Journal of Oncology. 1994 ; Vol. 5, No. 6. pp. 1369-1374.
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