TY - JOUR
T1 - Effect of preterm birth on later FEV1
T2 - a systematic review and meta-analysis
AU - Kotecha, Sarah Joanne
AU - Edwards, Martin O
AU - Watkins, W. John
AU - Henderson, A John
AU - Paranjothy, Shantini
AU - Dunstan, Frank D.
AU - Kotecha, Sailesh
N1 - Acknowledgements:
We are very grateful to Mala Mann and Ruth Turley based at the Support Unit for Research Evidence, Cardiff University for their support and help with developing the search strategy.
PY - 2013/7/9
Y1 - 2013/7/9
N2 - Background Increasing evidence suggests that preterm birth affects later lung function. We systematically reviewed the literature to determine whether percentage predicted forced expiratory volume in 1 s (%FEV1) is lower in later life in preterm-born subjects, with or without bronchopulmonary dysplasia (BPD), compared with term-born controls.
Methods: Studies reporting %FEV1, with or without a term-born control group, in later life for preterm-born subjects (<37 weeks gestation) were extracted from
eight databases. Data were analysed using Review Manager and STATA. The quality of the studies was assessed.
Results: From 8839 titles, 1124 full articles were screened and 59 were included: 28 studied preterm-born children without BPD, 24 with BPD28 (supplemental
oxygen dependency at 28 days), 15 with BPD36 (supplemental oxygen dependency 36 weeks postmenstrual age) and 34 born preterm. For the
preterm-born group without BPD and for the BPD28 and BPD36 groups the mean differences (and 95% CIs) for %FEV1 compared with term-born controls were −7.2% (−8.7% to −5.6%), −16.2% (−19.9% to −12.4%) and −18.9% (−21.1% to −16.7%), respectively. Pooling all data on preterm-born subjects whether or not
there was a control group gave a pooled %FEV1 estimate of 91.0% (88.8% to 93.1%) for the pretermborn cohort without BPD, 83.7% (80.2% to 87.2%) for
BPD28 and 79.1% (76.9% to 81.3%) for BPD36. Interestingly, %FEV1 for BPD28 has improved over the years.
Conclusions: %FEV1 is decreased in preterm-born survivors, even those who do not develop BPD. %FEV1 of survivors of BPD28 has improved over recent years.
Long-term respiratory follow-up of preterm-born survivors is required as they may be at risk of developing chronic obstructive pulmonary disease
AB - Background Increasing evidence suggests that preterm birth affects later lung function. We systematically reviewed the literature to determine whether percentage predicted forced expiratory volume in 1 s (%FEV1) is lower in later life in preterm-born subjects, with or without bronchopulmonary dysplasia (BPD), compared with term-born controls.
Methods: Studies reporting %FEV1, with or without a term-born control group, in later life for preterm-born subjects (<37 weeks gestation) were extracted from
eight databases. Data were analysed using Review Manager and STATA. The quality of the studies was assessed.
Results: From 8839 titles, 1124 full articles were screened and 59 were included: 28 studied preterm-born children without BPD, 24 with BPD28 (supplemental
oxygen dependency at 28 days), 15 with BPD36 (supplemental oxygen dependency 36 weeks postmenstrual age) and 34 born preterm. For the
preterm-born group without BPD and for the BPD28 and BPD36 groups the mean differences (and 95% CIs) for %FEV1 compared with term-born controls were −7.2% (−8.7% to −5.6%), −16.2% (−19.9% to −12.4%) and −18.9% (−21.1% to −16.7%), respectively. Pooling all data on preterm-born subjects whether or not
there was a control group gave a pooled %FEV1 estimate of 91.0% (88.8% to 93.1%) for the pretermborn cohort without BPD, 83.7% (80.2% to 87.2%) for
BPD28 and 79.1% (76.9% to 81.3%) for BPD36. Interestingly, %FEV1 for BPD28 has improved over the years.
Conclusions: %FEV1 is decreased in preterm-born survivors, even those who do not develop BPD. %FEV1 of survivors of BPD28 has improved over recent years.
Long-term respiratory follow-up of preterm-born survivors is required as they may be at risk of developing chronic obstructive pulmonary disease
U2 - 10.1136/thoraxjnl-2012-203079
DO - 10.1136/thoraxjnl-2012-203079
M3 - Article
VL - 68
SP - 760
EP - 766
JO - Thorax
JF - Thorax
SN - 0040-6376
IS - 8
ER -