TY - JOUR
T1 - Effect of sequential rounds of cervical cancer screening on management of HPV-positive women
T2 - A 15-year population-based cohort study from China
AU - Cruickshank, Maggie
AU - Xu, Xiao-Qian
AU - Rezhake, Remila
AU - Hu, Shang-Ying
AU - Chen, Feng
AU - Zhang, Xun
AU - Pan, Qin-Jing
AU - Zhang, Wen-Hua
AU - Ma, Jun-Fei
AU - Qiao, You-Lin
AU - Zhao, Fang-Hui
N1 - We acknowledge the significant contributions of all the investigators in CICAMS and local health providers for their efforts in conducting the study and women who participated in this study. This work was supported by National Natural Science Foundation of China (81761128006) and National Key R&D Program of China (2018YFC1315504).
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
PY - 2021/3
Y1 - 2021/3
N2 - Women are anticipated to go through more than two rounds of cervical screening in their lifetime. Human papillomavirus (HPV) testing is increasingly used as the primary cervical cancer screening test. However, triage strategies for HPV-positive women were usually evaluated at baseline screening. We assessed the effect of sequential rounds of cervical screening on several algorithms for HPV triage. A total of 1,997 women ages 35–45 years were enrolled in 1999 in Shanxi, P.R. China and followed up three times at approximately 5-year intervals. Cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) prevalence by prior HPV results and performance of 12 triage algorithms with cytology, genotyping, and prior HPV were examined among 229 HPV-positive women at the fourth round. CIN2+ prevalence varied from 56.5% (95% confidence interval, 36.8%–74.4%) following 15 years HPV persistence to 3.5% (1.2%–9.9%) with an incident HPV within 15 years. Triage with cytology (with threshold of atypical squamous cells of undetermined significance) yielded positive predictive value (PPV) of 21.4% (13.8%–29.0%), entailing immediate colposcopic referral, and negative predictive value (NPV) of 97.4% (94.6%–100%), permitting retesting at short intervals. Triage with genotyping (16/18/31/33/45/52/58) or prior HPV results showed comparable performance with cytology. Among 11 triage algorithms with similar NPV to cytology, triage with prior HPV results and reflex genotyping (16/18) achieved highest PPV of 28.9% (18.8%–39.1%) and lowest colposcopy referral of 33.2% (27.4%–39.5%). HPV persistence across rounds is an effective risk stratifier in HPV-positive women. Mainstream cytology and genotyping, with or without consideration of prior HPV results, remain effective for HPV triage at fourth round.Prevention Relevance: The study highlights the sustainedeffectiveness of mainstream HPV triage methods, such ascytology and genotyping, after sequential rounds of cervicalscreening. It also suggests that use of HPV persistence acrossrounds can improve management of HPV-positive womenin cervical cancer screening.
AB - Women are anticipated to go through more than two rounds of cervical screening in their lifetime. Human papillomavirus (HPV) testing is increasingly used as the primary cervical cancer screening test. However, triage strategies for HPV-positive women were usually evaluated at baseline screening. We assessed the effect of sequential rounds of cervical screening on several algorithms for HPV triage. A total of 1,997 women ages 35–45 years were enrolled in 1999 in Shanxi, P.R. China and followed up three times at approximately 5-year intervals. Cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) prevalence by prior HPV results and performance of 12 triage algorithms with cytology, genotyping, and prior HPV were examined among 229 HPV-positive women at the fourth round. CIN2+ prevalence varied from 56.5% (95% confidence interval, 36.8%–74.4%) following 15 years HPV persistence to 3.5% (1.2%–9.9%) with an incident HPV within 15 years. Triage with cytology (with threshold of atypical squamous cells of undetermined significance) yielded positive predictive value (PPV) of 21.4% (13.8%–29.0%), entailing immediate colposcopic referral, and negative predictive value (NPV) of 97.4% (94.6%–100%), permitting retesting at short intervals. Triage with genotyping (16/18/31/33/45/52/58) or prior HPV results showed comparable performance with cytology. Among 11 triage algorithms with similar NPV to cytology, triage with prior HPV results and reflex genotyping (16/18) achieved highest PPV of 28.9% (18.8%–39.1%) and lowest colposcopy referral of 33.2% (27.4%–39.5%). HPV persistence across rounds is an effective risk stratifier in HPV-positive women. Mainstream cytology and genotyping, with or without consideration of prior HPV results, remain effective for HPV triage at fourth round.Prevention Relevance: The study highlights the sustainedeffectiveness of mainstream HPV triage methods, such ascytology and genotyping, after sequential rounds of cervicalscreening. It also suggests that use of HPV persistence acrossrounds can improve management of HPV-positive womenin cervical cancer screening.
U2 - 10.1158/1940-6207.CAPR-20-0456
DO - 10.1158/1940-6207.CAPR-20-0456
M3 - Article
C2 - 33303694
VL - 14
SP - 363
EP - 372
JO - Cancer Prevention Research
JF - Cancer Prevention Research
SN - 1940-6207
IS - 3
ER -
