Abstract
New evidence suggests that soy products might reduce chronic systemic inflammation. Therefore, we aimed to summarize the effect of soy isoflavones on serum concentration of C-reactive protein (CRP) among participants with chronic inflammatory disorders by conducting this study. Cochrane Library, Scopus, ISI Web of Science, clinicaltrials.gov, and PubMed were searched to identify randomized clinical trials (RCTs) published up to December 2020. The effect size was calculated by the mean change from baseline in concentrations of CRP and its standard deviation for both intervention and comparison groups. DerSimonian and Laird random-effects model was used when the heterogeneity test was statistically significant. In total, thirteen RCTs involving 1213 participants and ten RCTs involving 1052 participants were eligible for our systematic review and meta-analysis respectively. Study duration ranged from 4 to 96 weeks and soy isoflavones dose varied from 33 to 132 mg/day. Overall effect size indicated a non-significant effect on serum concentration of CRP following soy isoflavones intake (weighted mean differences (WMD)=-0.15 mg/L, 95% confidence interval (CI): -0.54, 0.23; p=0.430). Subgroup analysis revealed that soy isoflavones significantly reduced serum concentration of CRP in studies among participants with age >57 years and baseline CRP levels >3.75 mg/L. The present study proposed that soy isoflavones could not significantly reduce serum CRP levels. It seems more RCTs on participants with age more than 57 years and higher levels of CRP is necessary.
Original language | English |
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Pages (from-to) | 447-458 |
Number of pages | 12 |
Journal | International journal for vitamin and nutrition research |
Volume | 93 |
Issue number | 5 |
Early online date | 16 Mar 2022 |
DOIs | |
Publication status | Published - 1 Oct 2023 |
Bibliographical note
Acknowledgments:We are extremely grateful to the data collection team at the Neyshabur University of Medical Sciences.
Funding:
This study was financially supported by Neyshabur University of Medical Sciences (Grant number: 98-01-149; Ethical code: IR.NUMS.REC.1399.006).
Keywords
- Soy isoflavones
- systematic review
- meta-analysis
- C-reactive protein
- CARDIOVASCULAR RISK-FACTORS
- OBESE POSTMENOPAUSAL WOMEN
- LDL CHOLESTEROL
- DOUBLE-BLIND
- KAPPA-B
- EXERCISE
- SUPPLEMENTATION
- PHYTOESTROGENS
- CONSUMPTION
- CYTOKINES