Abstract
Background and aims: Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. Data synthesis: Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected. Conclusions: A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (-0.68 mmHg, 95%CI: -2.19 to 0.84), and DBP (-0.57 mmHg, 95%CI: -1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for 800 IU/day for
| Original language | English |
|---|---|
| Pages (from-to) | 663-673 |
| Number of pages | 11 |
| Journal | Nutrition, Metabolism, and Cardiovascular Diseases: NMCD |
| Volume | 26 |
| Issue number | 8 |
| Early online date | 25 Apr 2016 |
| DOIs | |
| Publication status | Published - 1 Aug 2016 |
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Keywords
- Blood pressure
- Cholecalciferol
- Hypertension
- Meta-analysis
- Vitamin D3 supplementation
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine
Cite this
Effect of vitamin D3 supplementation on blood pressure in adults : An updated meta-analysis. / Golzarand, M.; Shab-Bidar, S.; Koochakpoor, G.; Speakman, John Roger; Djafarian, K.
In: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, Vol. 26, No. 8, 01.08.2016, p. 663-673.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of vitamin D3 supplementation on blood pressure in adults
T2 - An updated meta-analysis
AU - Golzarand, M.
AU - Shab-Bidar, S.
AU - Koochakpoor, G.
AU - Speakman, John Roger
AU - Djafarian, K.
N1 - Funding No external funding or sponsorship was received for this work.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Background and aims: Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. Data synthesis: Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected. Conclusions: A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (-0.68 mmHg, 95%CI: -2.19 to 0.84), and DBP (-0.57 mmHg, 95%CI: -1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for 800 IU/day for
AB - Background and aims: Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. Data synthesis: Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected. Conclusions: A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (-0.68 mmHg, 95%CI: -2.19 to 0.84), and DBP (-0.57 mmHg, 95%CI: -1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for 800 IU/day for
KW - Blood pressure
KW - Cholecalciferol
KW - Hypertension
KW - Meta-analysis
KW - Vitamin D3 supplementation
UR - http://www.scopus.com/inward/record.url?scp=84973526748&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2016.04.011
DO - 10.1016/j.numecd.2016.04.011
M3 - Article
VL - 26
SP - 663
EP - 673
JO - Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
JF - Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
SN - 0939-4753
IS - 8
ER -