Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis

M. Golzarand, S. Shab-Bidar, G. Koochakpoor, John Roger Speakman, K. Djafarian

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Background and aims: Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. Data synthesis: Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected. Conclusions: A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (-0.68 mmHg, 95%CI: -2.19 to 0.84), and DBP (-0.57 mmHg, 95%CI: -1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for 800 IU/day for

Original languageEnglish
Pages (from-to)663-673
Number of pages11
JournalNutrition, Metabolism, and Cardiovascular Diseases: NMCD
Issue number8
Early online date25 Apr 2016
Publication statusPublished - 1 Aug 2016


  • Blood pressure
  • Cholecalciferol
  • Hypertension
  • Meta-analysis
  • Vitamin D3 supplementation


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