Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis

M. Golzarand; S. Shab-Bidar; G. Koochakpoor; John Roger Speakman; K. Djafarian

doi:10.1016/j.numecd.2016.04.011

Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis

M. Golzarand, S. Shab-Bidar, G. Koochakpoor, John Roger Speakman, K. Djafarian

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

Background and aims: Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. Data synthesis: Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected. Conclusions: A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (-0.68 mmHg, 95%CI: -2.19 to 0.84), and DBP (-0.57 mmHg, 95%CI: -1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for 800 IU/day for

Original language	English
Pages (from-to)	663-673
Number of pages	11
Journal	Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Volume	26
Issue number	8
Early online date	25 Apr 2016
DOIs	https://doi.org/10.1016/j.numecd.2016.04.011
Publication status	Published - 1 Aug 2016

Keywords

Blood pressure
Cholecalciferol
Hypertension
Meta-analysis
Vitamin D3 supplementation

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

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Golzarand, M., Shab-Bidar, S., Koochakpoor, G., Speakman, J. R., & Djafarian, K. (2016). Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 26(8), 663-673. https://doi.org/10.1016/j.numecd.2016.04.011

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abstract = "Background and aims: Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. Data synthesis: Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected. Conclusions: A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (-0.68 mmHg, 95%CI: -2.19 to 0.84), and DBP (-0.57 mmHg, 95%CI: -1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for 800 IU/day for ",

keywords = "Blood pressure, Cholecalciferol, Hypertension, Meta-analysis, Vitamin D3 supplementation",

author = "M. Golzarand and S. Shab-Bidar and G. Koochakpoor and Speakman, {John Roger} and K. Djafarian",

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AU - Speakman, John Roger

AU - Djafarian, K.

N1 - Funding No external funding or sponsorship was received for this work.

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N2 - Background and aims: Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. Data synthesis: Literature searches of PubMed, Scopus, Ovid, and Google scholar for publications in English were conducted up to April 2015. RCTs that assessed the effect of VD3S on SBP and DBP were selected. Conclusions: A total of 30 RCTs with 41 arms including 4744 participants were included. The mean duration of the studies was 5.6 ± 4.0 months, and doses of VD3S varied between 200 and 12,000 IU/day. VD3S had no effect on SBP (-0.68 mmHg, 95%CI: -2.19 to 0.84), and DBP (-0.57 mmHg, 95%CI: -1.36 to 0.22). Subgroup analysis revealed that daily vitamin D3 therapy at a dose of >800 IU/day for 800 IU/day for

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