Abstract
Nutritional backgrounds prior to pregnancy may interact with subsequent gestational intake to influence pregnancy outcome, particularly in young, growing adolescents. To investigate this interaction, singleton pregnancies were established in two groups of adolescent sheep of identical age but different initial weight and adiposity score, classified as good (G) and poor (P) body mass index (BMI). Thereafter, ewes were offered either an optimal control (C) intake to maintain adiposity throughout pregnancy, undernourished (UN) to maintain weight at conception but deplete maternal body reserves, or overnourished (ON) to promote rapid maternal growth and adiposity, resulting in a 2 x 3 factorial design. Gestation length was independent of BMI and reduced in ON dams. Average placental and lamb birth weights were influenced by initial BMI (G > P) and gestational intake (C > UN > ON), with the highest incidence of growth restriction in ON groups. Metabolic challenges at two thirds of gestation revealed enhanced insulin insensitivity in ON dams (higher glucose postinsulin challenge and higher insulin post-glucose challenge), but nevertheless fetal growth was constrained. Initial colostrum yield, total IgG, and nutrient supply were reduced in ON groups, but these low-birth-weight lambs exhibited rapid catch-up growth to weaning. Thus, both maternal BMI at conception and gestational intake have a profound influence on pregnancy outcome in young, putatively growing adolescent sheep and may have implications for the nutritional management of pregnant adolescent humans.
| Original language | English |
|---|---|
| Pages (from-to) | 320-330 |
| Number of pages | 11 |
| Journal | Biology of Reproduction |
| Volume | 82 |
| Issue number | 2 |
| Early online date | 30 Sep 2009 |
| DOIs | |
| Publication status | Published - 1 Feb 2010 |
Keywords
- adolescent pregnancy
- body mass index
- colostrum
- female reproductive tract
- fetus
- gestational weight gain
- growth
- placenta
- pregnancy
- uterus
- body-mass index
- growing adolescent
- fetal-growth
- maternal weight
- placental growth
- birth-weight
- preterm delivery
- gain
- ewes
- nutrition
Cite this
Effect of Weight and Adiposity at Conception and Wide Variations in Gestational Dietary Intake on Pregnancy Outcome and Early Postnatal Performance in Young Adolescent Sheep. / Wallace, Jacqueline; Milne, John; Aitken, Raymond.
In: Biology of Reproduction, Vol. 82, No. 2, 01.02.2010, p. 320-330.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of Weight and Adiposity at Conception and Wide Variations in Gestational Dietary Intake on Pregnancy Outcome and Early Postnatal Performance in Young Adolescent Sheep
AU - Wallace, Jacqueline
AU - Milne, John
AU - Aitken, Raymond
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Nutritional backgrounds prior to pregnancy may interact with subsequent gestational intake to influence pregnancy outcome, particularly in young, growing adolescents. To investigate this interaction, singleton pregnancies were established in two groups of adolescent sheep of identical age but different initial weight and adiposity score, classified as good (G) and poor (P) body mass index (BMI). Thereafter, ewes were offered either an optimal control (C) intake to maintain adiposity throughout pregnancy, undernourished (UN) to maintain weight at conception but deplete maternal body reserves, or overnourished (ON) to promote rapid maternal growth and adiposity, resulting in a 2 x 3 factorial design. Gestation length was independent of BMI and reduced in ON dams. Average placental and lamb birth weights were influenced by initial BMI (G > P) and gestational intake (C > UN > ON), with the highest incidence of growth restriction in ON groups. Metabolic challenges at two thirds of gestation revealed enhanced insulin insensitivity in ON dams (higher glucose postinsulin challenge and higher insulin post-glucose challenge), but nevertheless fetal growth was constrained. Initial colostrum yield, total IgG, and nutrient supply were reduced in ON groups, but these low-birth-weight lambs exhibited rapid catch-up growth to weaning. Thus, both maternal BMI at conception and gestational intake have a profound influence on pregnancy outcome in young, putatively growing adolescent sheep and may have implications for the nutritional management of pregnant adolescent humans.
AB - Nutritional backgrounds prior to pregnancy may interact with subsequent gestational intake to influence pregnancy outcome, particularly in young, growing adolescents. To investigate this interaction, singleton pregnancies were established in two groups of adolescent sheep of identical age but different initial weight and adiposity score, classified as good (G) and poor (P) body mass index (BMI). Thereafter, ewes were offered either an optimal control (C) intake to maintain adiposity throughout pregnancy, undernourished (UN) to maintain weight at conception but deplete maternal body reserves, or overnourished (ON) to promote rapid maternal growth and adiposity, resulting in a 2 x 3 factorial design. Gestation length was independent of BMI and reduced in ON dams. Average placental and lamb birth weights were influenced by initial BMI (G > P) and gestational intake (C > UN > ON), with the highest incidence of growth restriction in ON groups. Metabolic challenges at two thirds of gestation revealed enhanced insulin insensitivity in ON dams (higher glucose postinsulin challenge and higher insulin post-glucose challenge), but nevertheless fetal growth was constrained. Initial colostrum yield, total IgG, and nutrient supply were reduced in ON groups, but these low-birth-weight lambs exhibited rapid catch-up growth to weaning. Thus, both maternal BMI at conception and gestational intake have a profound influence on pregnancy outcome in young, putatively growing adolescent sheep and may have implications for the nutritional management of pregnant adolescent humans.
KW - adolescent pregnancy
KW - body mass index
KW - colostrum
KW - female reproductive tract
KW - fetus
KW - gestational weight gain
KW - growth
KW - placenta
KW - pregnancy
KW - uterus
KW - body-mass index
KW - growing adolescent
KW - fetal-growth
KW - maternal weight
KW - placental growth
KW - birth-weight
KW - preterm delivery
KW - gain
KW - ewes
KW - nutrition
U2 - 10.1095/biolreprod.109.080069
DO - 10.1095/biolreprod.109.080069
M3 - Article
VL - 82
SP - 320
EP - 330
JO - Biology of Reproduction
JF - Biology of Reproduction
SN - 0006-3363
IS - 2
ER -