Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity.

Risa Kudo, Masayuki Sekine* (Corresponding Author), Manako Yamaguchi, Megumi Hara, Sharon J. B. Hanley, Megumi Kurosawa, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Japanese girls aged 12-16 years are offered free human papillomavirus (HPV) vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study comprised women aged 20-26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5194 women registered for this study, final analyses included 3167 women in the vaccinated group (2821 vaccinated women prior to sexual debut) and 1386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%), and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (P 
Original languageEnglish
Pages (from-to)3211-3220
Number of pages10
JournalCancer Science
Volume113
Issue number9
Early online date11 Jul 2022
DOIs
Publication statusPublished - 1 Sep 2022

Keywords

  • cervical cancer
  • cytological abnormality
  • HPV infection
  • HPV vaccine
  • sexual activity

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