Abstract
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated inflammatory host response to infection, characterised by cytokine release and oxidative stress. Caspase-1 activation and interleukin (IL-1β) release are classical indicators of inflammasome activation. 6-hydroxymelatonin (6OHM) is the main metabolite of melatonin and has potent antioxidant and anti-inflammatory activity. However little is known about its mode of action. The aim of this study was to investigate the effects of 6OHM in a human macrophage model of inflammasome activation under conditions mimicking sepsis
Original language | English |
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Pages (from-to) | E79-E80 |
Number of pages | 2 |
Journal | British Journal of Anaesthesia |
Volume | 126 |
Issue number | 2 |
Early online date | 16 Jan 2021 |
DOIs | |
Publication status | Published - 19 Feb 2021 |
Event | Anaesthesia Research Conference - London Duration: 24 Nov 2020 → 24 Nov 2020 |