Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis

Research output: Contribution to journalAbstractpeer-review

Abstract

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated inflammatory host response to infection, characterised by cytokine release and oxidative stress. Caspase-1 activation and interleukin (IL-1β) release are classical indicators of inflammasome activation. 6-hydroxymelatonin (6OHM) is the main metabolite of melatonin and has potent antioxidant and anti-inflammatory activity. However little is known about its mode of action. The aim of this study was to investigate the effects of 6OHM in a human macrophage model of inflammasome activation under conditions mimicking sepsis
Original languageEnglish
Pages (from-to)E79-E80
Number of pages2
JournalBritish Journal of Anaesthesia
Volume126
Issue number2
Early online date16 Jan 2021
DOIs
Publication statusPublished - 19 Feb 2021
EventAnaesthesia Research Conference - London
Duration: 24 Nov 2020 → …

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