EFFECTS OF CETIRIZINE ON HUMAN EOSINOPHIL AND NEUTROPHIL ACTIVATION INVITRO

Garry Michael Walsh, R MOQBEL, A HARTNELL, A B KAY

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The ability of cetirizine, a novel antihistamine agent, to inhibit the in vivo activation of human eosinophils, neutrophils and monocytes has been investigated using C3b- and IgG-dependent rosette formation, cytotoxicity against opsonised parasitic larvae and adherence to plasma-coated glass (PCG). The drug inhibited platelet-activating factor (PAF)-induced enhancement of eosinophil and neutrophil IgG (Fc) and complement (C3b) rosettes with an IC50 of 2 x 10(-5) M. There was also comparable inhibition of PAF-dependent enhancement of eosinophil cytotoxicity (for complement-coated schistosomula of Schistosoma mansoni). Cetirizine inhibited PAF-induced eosinophil, but not neutrophil, hyperadherence to PCG. These data support the view that cetirizine may exert some of its anti-allergic effects by inhibiting the activation of human granulocytes and that it may also selectively inhibit PAF-induced eosinophil hyperadherence.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalInternational Archives of Allergy and Applied Immunology
Volume95
Issue number2-3
Publication statusPublished - 1991

Keywords

  • COMPLEMENT RECEPTORS
  • CELLS-INVITRO
  • EXPRESSION
  • LEUKOCYTE
  • ADHESION
  • STIMULATION
  • ENHANCEMENT
  • ADHERENCE
  • BINDING

Cite this

EFFECTS OF CETIRIZINE ON HUMAN EOSINOPHIL AND NEUTROPHIL ACTIVATION INVITRO. / Walsh, Garry Michael; MOQBEL, R ; HARTNELL, A ; KAY, A B .

In: International Archives of Allergy and Applied Immunology, Vol. 95, No. 2-3, 1991, p. 158-162.

Research output: Contribution to journalArticle

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abstract = "The ability of cetirizine, a novel antihistamine agent, to inhibit the in vivo activation of human eosinophils, neutrophils and monocytes has been investigated using C3b- and IgG-dependent rosette formation, cytotoxicity against opsonised parasitic larvae and adherence to plasma-coated glass (PCG). The drug inhibited platelet-activating factor (PAF)-induced enhancement of eosinophil and neutrophil IgG (Fc) and complement (C3b) rosettes with an IC50 of 2 x 10(-5) M. There was also comparable inhibition of PAF-dependent enhancement of eosinophil cytotoxicity (for complement-coated schistosomula of Schistosoma mansoni). Cetirizine inhibited PAF-induced eosinophil, but not neutrophil, hyperadherence to PCG. These data support the view that cetirizine may exert some of its anti-allergic effects by inhibiting the activation of human granulocytes and that it may also selectively inhibit PAF-induced eosinophil hyperadherence.",
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AU - MOQBEL, R

AU - HARTNELL, A

AU - KAY, A B

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Y1 - 1991

N2 - The ability of cetirizine, a novel antihistamine agent, to inhibit the in vivo activation of human eosinophils, neutrophils and monocytes has been investigated using C3b- and IgG-dependent rosette formation, cytotoxicity against opsonised parasitic larvae and adherence to plasma-coated glass (PCG). The drug inhibited platelet-activating factor (PAF)-induced enhancement of eosinophil and neutrophil IgG (Fc) and complement (C3b) rosettes with an IC50 of 2 x 10(-5) M. There was also comparable inhibition of PAF-dependent enhancement of eosinophil cytotoxicity (for complement-coated schistosomula of Schistosoma mansoni). Cetirizine inhibited PAF-induced eosinophil, but not neutrophil, hyperadherence to PCG. These data support the view that cetirizine may exert some of its anti-allergic effects by inhibiting the activation of human granulocytes and that it may also selectively inhibit PAF-induced eosinophil hyperadherence.

AB - The ability of cetirizine, a novel antihistamine agent, to inhibit the in vivo activation of human eosinophils, neutrophils and monocytes has been investigated using C3b- and IgG-dependent rosette formation, cytotoxicity against opsonised parasitic larvae and adherence to plasma-coated glass (PCG). The drug inhibited platelet-activating factor (PAF)-induced enhancement of eosinophil and neutrophil IgG (Fc) and complement (C3b) rosettes with an IC50 of 2 x 10(-5) M. There was also comparable inhibition of PAF-dependent enhancement of eosinophil cytotoxicity (for complement-coated schistosomula of Schistosoma mansoni). Cetirizine inhibited PAF-induced eosinophil, but not neutrophil, hyperadherence to PCG. These data support the view that cetirizine may exert some of its anti-allergic effects by inhibiting the activation of human granulocytes and that it may also selectively inhibit PAF-induced eosinophil hyperadherence.

KW - COMPLEMENT RECEPTORS

KW - CELLS-INVITRO

KW - EXPRESSION

KW - LEUKOCYTE

KW - ADHESION

KW - STIMULATION

KW - ENHANCEMENT

KW - ADHERENCE

KW - BINDING

M3 - Article

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SP - 158

EP - 162

JO - International Archives of Allergy and Applied Immunology

JF - International Archives of Allergy and Applied Immunology

SN - 0020-5915

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ER -