Effects of dietary restriction on metabolic and cognitive health

Mirela Delibegovic, Marina Souza Matos* (Corresponding Author), Bettina Platt

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Life expectancy in most developed countries has been rising over the last
century. In the UK alone, there are around 12 million people over 65
years old and centenarians have increased by 85% in the past 15 years.
As a result of our ageing population, which is due mainly to
improvements in medical treatments, public health, improved housing
and lifestyle choices, there is an associated increase in prevalence of
pathological conditions, such as metabolic disorders, type 2 diabetes
(T2D), cardiovascular and neurodegenerative diseases, many types of
cancer and others. Statistics suggest that nearly 54% of elderly people
in the UK live with at least two chronic conditions, revealing the urgency
for identifying interventions that can prevent and/or treat such disorders.
Non-pharmacological, dietary interventions such as caloric restriction
(CR) and methionine restriction (MR) have revealed promising outcomes
in increasing longevity and preventing and/or reversing the development
of ageing-associated disorders. In this review, we discuss the evidence
and mechanisms that are involved in these processes. FGF21 and H2S
are important molecules involved in the effects of CR and MR in the
extension of life span. Their role is also associated with the prevention of
metabolic and cognitive disorders, highlighting these interventions as
promising modulators for improvement of health span.
Original languageEnglish
Pages (from-to)1-34
Number of pages34
JournalProceedings of the Nutrition Society
Early online date3 Nov 2020
DOIs
Publication statusE-pub ahead of print - 3 Nov 2020

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