Abstract
Life expectancy in most developed countries has been rising over the last
century. In the UK alone, there are around 12 million people over 65
years old and centenarians have increased by 85% in the past 15 years.
As a result of our ageing population, which is due mainly to
improvements in medical treatments, public health, improved housing
and lifestyle choices, there is an associated increase in prevalence of
pathological conditions, such as metabolic disorders, type 2 diabetes
(T2D), cardiovascular and neurodegenerative diseases, many types of
cancer and others. Statistics suggest that nearly 54% of elderly people
in the UK live with at least two chronic conditions, revealing the urgency
for identifying interventions that can prevent and/or treat such disorders.
Non-pharmacological, dietary interventions such as caloric restriction
(CR) and methionine restriction (MR) have revealed promising outcomes
in increasing longevity and preventing and/or reversing the development
of ageing-associated disorders. In this review, we discuss the evidence
and mechanisms that are involved in these processes. FGF21 and H2S
are important molecules involved in the effects of CR and MR in the
extension of life span. Their role is also associated with the prevention of
metabolic and cognitive disorders, highlighting these interventions as
promising modulators for improvement of health span.
century. In the UK alone, there are around 12 million people over 65
years old and centenarians have increased by 85% in the past 15 years.
As a result of our ageing population, which is due mainly to
improvements in medical treatments, public health, improved housing
and lifestyle choices, there is an associated increase in prevalence of
pathological conditions, such as metabolic disorders, type 2 diabetes
(T2D), cardiovascular and neurodegenerative diseases, many types of
cancer and others. Statistics suggest that nearly 54% of elderly people
in the UK live with at least two chronic conditions, revealing the urgency
for identifying interventions that can prevent and/or treat such disorders.
Non-pharmacological, dietary interventions such as caloric restriction
(CR) and methionine restriction (MR) have revealed promising outcomes
in increasing longevity and preventing and/or reversing the development
of ageing-associated disorders. In this review, we discuss the evidence
and mechanisms that are involved in these processes. FGF21 and H2S
are important molecules involved in the effects of CR and MR in the
extension of life span. Their role is also associated with the prevention of
metabolic and cognitive disorders, highlighting these interventions as
promising modulators for improvement of health span.
| Original language | English |
|---|---|
| Pages (from-to) | 126–138 |
| Number of pages | 13 |
| Journal | Proceedings of the Nutrition Society |
| Volume | 80 |
| Issue number | 2 |
| Early online date | 3 Nov 2020 |
| DOIs | |
| Publication status | Published - May 2021 |
| Event | Nutrition Society Live 2020 - Virtual event Duration: 14 Jul 2020 → 15 Jul 2020 https://www.nutritionsociety.org/events/nutrition-society-live-2020 |
Keywords
- Ageing
- Metabolism
- Methionine restriction
- Dietary restriction
- Cognition
Access to Document
- SouzaMatos_etal_PNS_Effects_of_dietary_AAM
This article has been accepted for publication and will appear in a revised form, subsequent to peer review and/or editorial input by Cambridge University Press, in Proceedings of the Nutrition Society published by Cambridge University Press, © Copyright CUP 2020