Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters

T Polyviou, C Easton , L Beis, D Malkova, P Takas, C Hambly, J R Speakman, K Koehler, Y P Pitsiladis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects. However, the scientific basis of the inclusion of Gly as a “masking agent” remains inconclusive. The purpose of this study was to determine the effects of a hyperhydrating supplement containing Gly on doping-relevant blood parameters. Nine trained males ingested a hyperhydrating mixture twice per day for 7 days containing 1.0 g·kg-1 body mass (BM) of Gly, 10.0 g of creatine and 75.0 g of glucose. Blood samples were collected and total hemoglobin (Hb) mass determined using the optimized carbon monoxide (CO) rebreathing method pre- and post-supplementation. BM and total body water (TBW) increased significantly following supplementation by 1.1 ± 1.2 and 1.0 ± 1.2 L (BM, P < 0.01; TBW, P <0.01), respectively. This hyperhydration did not significantly alter plasma volume or any of the doping-relevant blood parameters (e.g., hematocrit, Hb, reticulocytes and total Hb-mass) even when Gly was clearly detectable in urine samples. In conclusion, this study shows that supplementation with hyperhydrating solution containing Gly for 7 days does not significantly alter doping-relevant blood parameters.
Original languageEnglish
Pages (from-to)1171-1186
Number of pages16
JournalNutrients
Volume4
Issue number9
Early online date31 Aug 2012
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Doping in Sports
creatine
Creatine
Glycerol
glycerol
Hemoglobins
Body Water
blood
hemoglobin
Plasma Volume
Reticulocytes
body water
Carbon Monoxide
Hematocrit
ergogenic aids
reticulocytes
Urine
carbon monoxide
Glucose
hematocrit

Keywords

  • masking agent
  • glycerol
  • creatine
  • hyperhydration
  • doping markers

Cite this

Polyviou, T., Easton , C., Beis, L., Malkova, D., Takas, P., Hambly, C., ... Pitsiladis, Y. P. (2012). Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters. Nutrients, 4(9), 1171-1186. https://doi.org/10.3390/nu4091171

Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters. / Polyviou, T; Easton , C; Beis, L; Malkova, D; Takas, P; Hambly, C; Speakman, J R; Koehler, K; Pitsiladis, Y P.

In: Nutrients, Vol. 4, No. 9, 09.2012, p. 1171-1186.

Research output: Contribution to journalArticle

Polyviou, T, Easton , C, Beis, L, Malkova, D, Takas, P, Hambly, C, Speakman, JR, Koehler, K & Pitsiladis, YP 2012, 'Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters' Nutrients, vol. 4, no. 9, pp. 1171-1186. https://doi.org/10.3390/nu4091171
Polyviou, T ; Easton , C ; Beis, L ; Malkova, D ; Takas, P ; Hambly, C ; Speakman, J R ; Koehler, K ; Pitsiladis, Y P. / Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters. In: Nutrients. 2012 ; Vol. 4, No. 9. pp. 1171-1186.
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