Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents

Rubén Nogueiras, Paul Pfluger, Sulay Tovar, Myrtha Arnold, Sharon E Mitchell, Amanda Morris, Diego Perez-Tilve, Maria J. Vázquez, Petra Wiedmer, Tamara R. Castañeda, Richard DiMarchi, Matthias Tschöp, Annette Schurmann, Hans Georg Joost, Lynda M. Williams, Wolfgang Langhans, Carlos Diéguez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

241 Citations (Scopus)


Ghrelin stimulates food intake and adiposity and thereby increases body weight ( BW) in rodents after central as well as peripheral administration. Recently, it was discovered that the gene precursor of ghrelin encoded another secreted and bioactive peptide named obestatin. First reports appeared to demonstrate that this peptide requires an amidation for its biological activity and acts through the orphan receptor, GPR-39. Obestatin was shown to have actions opposite to ghrelin on food intake, BW, and gastric emptying. In the present study, we failed to observe any effect of obestatin on food intake, BW, body composition, energy expenditure, locomotor activity, respiratory quotient, or hypothalamic neuropeptides involved in energy balance regulation. In agreement with the first report, we were unable to find any effect of obestatin on GH secretion in vivo. Moreover, we were unable to find mRNA expression of GPR-39, the putative obestatin receptor, in the hypothalamus of rats. Therefore, the results presented here do not support a role of the obestatin/GPR-39 system in the regulation of energy balance.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
Issue number1
Early online date28 Sep 2006
Publication statusPublished - 4 Jan 2007


  • brain-stem
  • ghrelin levels
  • food-intake
  • peptide
  • rat
  • expression
  • secretagogue
  • nucleus
  • leptin
  • gene


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