Effects of smoking and abstention from smoking on fibrinogen synthesis in humans

K A Hunter, P J Garlick, Iain Broom, Susan Elizabeth Anderson, M A McNurlan

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Cigarette smoking and hyperfibrinogenaemia are both significant risk factors for the development of cardiovascular disease. Two studies are described here which aimed to establish the metabolic mechanism responsible for the raised plasma fibrinogen concentration observed in smokers. Chronic smokers had a significantly elevated absolute rate of fibrinogen synthesis (ASR) compared with non-smokers (22.7 +/- 1.3 mg/kg per day versus 16.0 +/- 1.3 mg/kg per day; means +/- S.E.M., P < 0.01), with plasma levels of fibrinogen significantly correlated with fibrinogen synthesis (r = 0.65, P = 0.04). Unlike fibrinogen, plasma albumin concentrations were lower in smokers than in non-smokers (45 <plus/minus> 0.4 versus 47 +/- 0.7 g/l, P < 0.05), but there was no difference in rates of albumin synthesis between the two groups. Two weeks cessation from smoking by previously chronic smokers was associated with a rapid and marked fall in plasma fibrinogen concentration (from 3.06 <plus/minus> 0.11 g/l to 2.49 +/- 14 g/l, P < 0.001), and a significant reduction in ASR (a 33% reduction, from 24.1 <plus/minus> 1.7 to 16.1 +/- 1.0 mg/kg per day, P < 0.001). These studies suggest a primary role for increased synthesis in producing the hyperfibrinogenaemia associated with smoking. Moreover, abstention from smoking for a period of only 2 weeks induces a significant decrease in the rate of fibrinogen synthesis by the liver, with a concomitant reduction in the plasma fibrinogen concentration.

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalClinical Science
Volume100
Issue number4
Publication statusPublished - Apr 2001

Keywords

  • albumin synthesis
  • cardiovascular disease
  • cigarette smoking
  • fibrinogen synthesis
  • stable isotopes
  • CORONARY HEART-DISEASE
  • CIGARETTE-SMOKING
  • RISK-FACTORS
  • PLASMA-FIBRINOGEN
  • ACUTE STIMULATION
  • HEALTHY-MEN
  • ALBUMIN
  • DEGRADATION
  • SURVIVORS
  • PROTEINS
  • ®brinogen synthesis

Cite this

Hunter, K. A., Garlick, P. J., Broom, I., Anderson, S. E., & McNurlan, M. A. (2001). Effects of smoking and abstention from smoking on fibrinogen synthesis in humans. Clinical Science, 100(4), 459-465.

Effects of smoking and abstention from smoking on fibrinogen synthesis in humans. / Hunter, K A ; Garlick, P J ; Broom, Iain; Anderson, Susan Elizabeth; McNurlan, M A .

In: Clinical Science, Vol. 100, No. 4, 04.2001, p. 459-465.

Research output: Contribution to journalArticle

Hunter, KA, Garlick, PJ, Broom, I, Anderson, SE & McNurlan, MA 2001, 'Effects of smoking and abstention from smoking on fibrinogen synthesis in humans', Clinical Science, vol. 100, no. 4, pp. 459-465.
Hunter KA, Garlick PJ, Broom I, Anderson SE, McNurlan MA. Effects of smoking and abstention from smoking on fibrinogen synthesis in humans. Clinical Science. 2001 Apr;100(4):459-465.
Hunter, K A ; Garlick, P J ; Broom, Iain ; Anderson, Susan Elizabeth ; McNurlan, M A . / Effects of smoking and abstention from smoking on fibrinogen synthesis in humans. In: Clinical Science. 2001 ; Vol. 100, No. 4. pp. 459-465.
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AB - Cigarette smoking and hyperfibrinogenaemia are both significant risk factors for the development of cardiovascular disease. Two studies are described here which aimed to establish the metabolic mechanism responsible for the raised plasma fibrinogen concentration observed in smokers. Chronic smokers had a significantly elevated absolute rate of fibrinogen synthesis (ASR) compared with non-smokers (22.7 +/- 1.3 mg/kg per day versus 16.0 +/- 1.3 mg/kg per day; means +/- S.E.M., P < 0.01), with plasma levels of fibrinogen significantly correlated with fibrinogen synthesis (r = 0.65, P = 0.04). Unlike fibrinogen, plasma albumin concentrations were lower in smokers than in non-smokers (45 0.4 versus 47 +/- 0.7 g/l, P < 0.05), but there was no difference in rates of albumin synthesis between the two groups. Two weeks cessation from smoking by previously chronic smokers was associated with a rapid and marked fall in plasma fibrinogen concentration (from 3.06 0.11 g/l to 2.49 +/- 14 g/l, P < 0.001), and a significant reduction in ASR (a 33% reduction, from 24.1 1.7 to 16.1 +/- 1.0 mg/kg per day, P < 0.001). These studies suggest a primary role for increased synthesis in producing the hyperfibrinogenaemia associated with smoking. Moreover, abstention from smoking for a period of only 2 weeks induces a significant decrease in the rate of fibrinogen synthesis by the liver, with a concomitant reduction in the plasma fibrinogen concentration.

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KW - cardiovascular disease

KW - cigarette smoking

KW - fibrinogen synthesis

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KW - HEALTHY-MEN

KW - ALBUMIN

KW - DEGRADATION

KW - SURVIVORS

KW - PROTEINS

KW - ®brinogen synthesis

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JF - Clinical Science

SN - 0143-5221

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ER -