Effects of weight loss in overweight/obese individuals and long-term lipid outcomes

a systematic review

Amudha Sujatha Poobalan, Lorna Sharman Aucott, William Smith, Alison Avenell, R. Jung, J. Broom, Adrian Maxwell Grant

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

This paper aims to review the evidence for long-term effectiveness of weight loss on cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides in overweight/obese people. Current evidence is mostly based on short-term studies. A systematic review of long-term lipid outcomes of weight loss in studies published between 1966 and 2001, was conducted. Inclusion criteria included all cohort studies and trials carried out on participants with body mass index of greater than or equal to 28 kg m-2. Studies had at least two weight change measurements and follow-up of more than 2 years. Thirteen long-term studies with a follow-up of more than 2 years were included. Cholesterol has a significant positive linear relationship with weight change (r = 0.89) where change in weight explains about 80% of the cholesterol difference variation (Adj R2 = 0.80). For every 10 kg weight loss a drop of 0.23 mmol L-1 in cholesterol may be expected for a person suffering from obesity or are grossly overweight. Weight loss has long-term beneficial effects especially on LDL and cholesterol. Weight loss in obese patients should be encouraged and sustained.
Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalObesity Reviews
Volume5
Issue number1
DOIs
Publication statusPublished - Feb 2004

Fingerprint

Weight Loss
Lipids
Cholesterol
Weights and Measures
LDL Cholesterol
HDL Cholesterol
Body Mass Index
Cohort Studies
Obesity

Keywords

  • cholesterol
  • lipids
  • long-term (>2 years)
  • weight loss
  • body mass index
  • humans
  • HDL cholesterol
  • LDL cholesterol
  • obesity
  • regression analysis
  • triglycerides
  • weight loss

Cite this

Effects of weight loss in overweight/obese individuals and long-term lipid outcomes : a systematic review. / Poobalan, Amudha Sujatha; Aucott, Lorna Sharman; Smith, William; Avenell, Alison; Jung, R.; Broom, J.; Grant, Adrian Maxwell.

In: Obesity Reviews, Vol. 5, No. 1, 02.2004, p. 43-50.

Research output: Contribution to journalArticle

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