TY - JOUR
T1 - Effects on (neuro)developmental and behavioral outcome at 2 years of age of induced labor compared with expectant management in intrauterine growth-restricted infants
T2 - Long-term outcomes of the DIGITAT trial
AU - Van Wyk, Linda
AU - Boers, Kim E.
AU - Van Der Post, Joris A.M.
AU - Van Pampus, Maria G.
AU - Van Wassenaer, Aleid G.
AU - Van Baar, Anneloes L.
AU - Spaanderdam, Marc E.A.
AU - Becker, Jeroen H.
AU - Kwee, Anneke
AU - Duvekot, Johannes J.
AU - Bremer, Henk A.
AU - Delemarre, Friso M.C.
AU - Bloemenkamp, Kitty W.M.
AU - De Groot, Christianne J.M.
AU - Willekes, Christine
AU - Roumen, Frans J.M.E.
AU - Van Lith, Jan M.M.
AU - Mol, Ben W.J.
AU - Le Cessie, Saskia
AU - Scherjon, Sicco A.
PY - 2012/5
Y1 - 2012/5
N2 - Objective: We sought to study long-term (neuro)developmental and behavioral outcome of pregnancies complicated by intrauterine growth restriction at term in relation to induction of labor or an expectant management. Study Design: Parents of 2-year-old children included in the Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT) answered the Ages and Stages Questionnaire (ASQ) and Child Behavior Checklist (CBCL). Results: We approached 582 (89.5%) of 650 parents. The response rate was 50%. Of these children, 27% had an abnormal score on the ASQ and 13% on the CBCL. Results of the ASQ and the CBCL for the 2 policies were comparable. Low birthweight, positive Morbidity Assessment Index score, and admission to intermediate care increased the risk of an abnormal outcome of the ASQ. This effect was not seen for the CBCL. Conclusion: In women with intrauterine growth restriction at term, neither a policy of induction of labor nor expectant management affect developmental and behavioral outcome when compared to expectant management.
AB - Objective: We sought to study long-term (neuro)developmental and behavioral outcome of pregnancies complicated by intrauterine growth restriction at term in relation to induction of labor or an expectant management. Study Design: Parents of 2-year-old children included in the Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT) answered the Ages and Stages Questionnaire (ASQ) and Child Behavior Checklist (CBCL). Results: We approached 582 (89.5%) of 650 parents. The response rate was 50%. Of these children, 27% had an abnormal score on the ASQ and 13% on the CBCL. Results of the ASQ and the CBCL for the 2 policies were comparable. Low birthweight, positive Morbidity Assessment Index score, and admission to intermediate care increased the risk of an abnormal outcome of the ASQ. This effect was not seen for the CBCL. Conclusion: In women with intrauterine growth restriction at term, neither a policy of induction of labor nor expectant management affect developmental and behavioral outcome when compared to expectant management.
KW - Ages and Stages Questionnaire
KW - Child Behavior Checklist
KW - DIGITAT trial
KW - intrauterine growth restriction
KW - long-term outcome
UR - http://www.scopus.com/inward/record.url?scp=84860296441&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2012.02.003
DO - 10.1016/j.ajog.2012.02.003
M3 - Article
AN - SCOPUS:84860296441
SN - 0002-9378
VL - 206
SP - 406.e1-406.e7
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5
ER -