Efficacy and tolerability of formoterol Turbuhaler in children

A. Von Berg, S. F. Papageorgiou, S. Wille, T. Carrillo, C. Kattamis, Peter Joseph Benedict Helms

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20 Citations (Scopus)

Abstract

A randomised, double-blind trial was undertaken to investigate the efficacy and tolerability of-formoterol Turbuhaler(R) in children with mild to moderate asthma. After a two-week run-in, 248 children aged 6-17 years were randomised to receive formoterol 4.5 and 9 mug b.i.d. or placebo for 12 weeks. Morning PEF (primary variable), was significantly improved versus placebo only in the formoterol 9 mug b.i.d. group (13 l/min, 95% CI: 1.9, 24.2%; p = 0.02). Both formoterol 4.5 and 9 mug significantly increased the pre-bronchodilator FEV, by 5.2-6.7% (p < 0.05) and reduced use of daytime relief medication versus placebo (p < 0.05). Formoterol 9 mug significantly reduced night-time reliever use and awakenings due to asthma versus placebo (p < 0.05). Both doses of formoterol were as well tolerated as placebo. In conclusion, formoterol 4.5 and 9 &mu;g b.i.d. is effective and well tolerated as maintenance therapy in children with mild to moderate asthma.

Original languageEnglish
Pages (from-to)852-856
Number of pages4
JournalInternational Journal of Clinical Practice
Volume57
Issue number10
Publication statusPublished - 2003

Keywords

  • ASTHMATIC-CHILDREN
  • PERSISTENT ASTHMA
  • INHALED CORTICOSTEROIDS
  • SALMETEROL XINAFOATE
  • SYMPTOMATIC ASTHMA
  • BUDESONIDE
  • ADOLESCENTS
  • SALBUTAMOL
  • POWDER
  • ONSET

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