Efficacité et tolérance des capsaïcinoïdes topiques dans le traitement de la douleur neuropathique: Une revue systématique et méta-analyse des essais cliniques randomisés

Translated title of the contribution: Efficacy and tolerance of topical capsaicinoids in the treatment of neuropathic pain : A systematic review and meta-analysis of randomized controlled trials

A.U. Trillig, R. Deumens, A. Mouraux, F. Bauchy, P. Forget* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction
Neuropathic pain is frequent and its management can be difficult in case of unsuccessful treatment and side effects. An alternative to systemic treatments is the topical use of capsaicinoids. The goal of this work is to evaluate the efficacy of the topical use of capsaicinoids to treat neuropathic pain.

Method
In agreement with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic research of clinical trials published between 1/1/1990 and 31/08/2014, in English and French, was performed in PubMed/Central and the Cochrane Database. The indications, modalities of treatment and therapeutic results were registered. Qualitative and quantitative (meta-) analyses of the data were performed.

Results
Seventeen studies were included, from 153 identified works. The extracted data permitted us to conclude that capsaicin is efficient in treating post-herpetic neuropathic pain as distal HIV-associated polyneuropathy. The data are insufficient to conclude whether the indications may be broadened.

Conclusion
Topical capsaicin is effective in treating postherpetic and HIV-associated neuropathic pain. Further studies are needed to evaluate other indications and the potential place of other capsaicinoids.
Translated title of the contributionEfficacy and tolerance of topical capsaicinoids in the treatment of neuropathic pain : A systematic review and meta-analysis of randomized controlled trials
Original languageFrench
Pages (from-to)239–249
Number of pages11
JournalDouleur et Analgesie
Volume30
Issue number4
Early online date24 Aug 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Capsaicine
  • Capsaicinoids
  • Neuropathic pain

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