Efficacy of daratumumab combination regimen in patients with multiple myeloma: A combined analysis of phase III randomized controlled trials

Thura W. Htut* (Corresponding Author), Kyaw Z. Thein, Alastair Lawrie, Jane Tighe, Gavin Preston

*Corresponding author for this work

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Abstract

Abstract The use of the CD38 monoclonal antibody daratumumab in combination with standard myeloma chemotherapy regimens has been studied extensively in recent years. We undertook an updated meta-analysis of phase III randomized controlled trials (RCT) to determine the efficacy of daratumumab combination regimens. The relative risk for progression was significantly lower in daratumumab-treated cohorts (HR 0.46, 95% CI 0.38-0.55) and this was consistent across newly diagnosed and relapsed cases. No statistically significant improvement was identified in newly diagnosed patients with high-risk cytogenetics and this group remains a therapeutic challenge.
Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournaleJHaem
Volume1
Issue number1
Early online date23 Jun 2020
DOIs
Publication statusPublished - Jul 2020

Bibliographical note

Open Access via the Jis Wiley Agreement

Keywords

  • daratumumab
  • meta-analysis
  • multiple myeloma
  • phase III randomized controlled trials

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