Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

Andrea Correa-Pérez; Iosef Abraha; Antonio Cherubini; Avril Collinson; Dominique Dardevet; Lisette CPGM de Groot; Marian A.E. de van der Schueren; Antje Hebestreit; Mary Hickson; Javier Jaramillo-Hidalgo; Isabel Lozano-Montoya; Denis O’Mahony; Roy L. Soiza; Marjolein Visser; Dorothee Volkert; Maike Wolters; Alfonso J. Cruz Jentoft

doi:10.1016/j.arr.2018.10.011

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

Andrea Correa-Pérez (Corresponding Author), Iosef Abraha, Antonio Cherubini, Avril Collinson, Dominique Dardevet, Lisette CPGM de Groot, Marian A.E. de van der Schueren, Antje Hebestreit, Mary Hickson, Javier Jaramillo-Hidalgo, Isabel Lozano-Montoya, Denis O’Mahony, Roy L. Soiza, Marjolein Visser, Dorothee Volkert, Maike Wolters, Alfonso J. Cruz Jentoft

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

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Abstract

INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.

Original language	English
Pages (from-to)	27-48
Number of pages	22
Journal	Ageing Research Reviews
Volume	49
Early online date	2 Nov 2018
DOIs	https://doi.org/10.1016/j.arr.2018.10.011
Publication status	Published - Jan 2019

Bibliographical note

The preparation of this paper was supported by the MalNutrition in the ELderly (MaNuEL) knowledge hub. MaNuEL is supported by the Joint Programming Initiative ‘Healthy Diet for a Healthy Life’. The MaNuEL funding agencies supporting this paper are (in alphabetical order of participating Member State): France: Ecole Supérieure d’Agricultires (ESA); Germany: Federal Ministry of Food and Agriculture (BMEL) represented by Federal Office for Agriculture and Food (BLE); The Netherlands: The Netherlands Organisation for Health Research and Development (ZonMw). This work was also supported by the SENATOR trial (FP7-HEALTH-2012-305930).

Keywords

protein energy malnutrition
elderly
review
dietary supplementation
systematic
Elderly, dietary supplementation
Review, systematic
Protein energy malnutrition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Correa-Pérez, A., Abraha, I., Cherubini, A., Collinson, A., Dardevet, D., de Groot, L. CPGM., de van der Schueren, M. A. E., Hebestreit, A., Hickson, M., Jaramillo-Hidalgo, J., Lozano-Montoya, I., O’Mahony, D., Soiza, R. L., Visser, M., Volkert, D., Wolters, M., & Jentoft, A. J. C. (2019). Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project. Ageing Research Reviews, 49, 27-48. https://doi.org/10.1016/j.arr.2018.10.011

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project. / Correa-Pérez, Andrea (Corresponding Author); Abraha, Iosef; Cherubini, Antonio et al.
In: Ageing Research Reviews, Vol. 49, 01.2019, p. 27-48.

Research output: Contribution to journal › Article › peer-review

Correa-Pérez, A, Abraha, I, Cherubini, A, Collinson, A, Dardevet, D, de Groot, LCPGM, de van der Schueren, MAE, Hebestreit, A, Hickson, M, Jaramillo-Hidalgo, J, Lozano-Montoya, I, O’Mahony, D, Soiza, RL, Visser, M, Volkert, D, Wolters, M & Jentoft, AJC 2019, 'Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project', Ageing Research Reviews, vol. 49, pp. 27-48. https://doi.org/10.1016/j.arr.2018.10.011

Correa-Pérez A, Abraha I, Cherubini A, Collinson A, Dardevet D, de Groot LCPGM et al. Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project. Ageing Research Reviews. 2019 Jan;49:27-48. Epub 2018 Nov 2. doi: 10.1016/j.arr.2018.10.011

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title = "Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project",

abstract = "INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.",

keywords = "protein energy malnutrition, elderly, review, dietary supplementation, systematic, Elderly, dietary supplementation, Review, systematic, Protein energy malnutrition",

author = "Andrea Correa-P{\'e}rez and Iosef Abraha and Antonio Cherubini and Avril Collinson and Dominique Dardevet and {de Groot}, {Lisette CPGM} and {de van der Schueren}, {Marian A.E.} and Antje Hebestreit and Mary Hickson and Javier Jaramillo-Hidalgo and Isabel Lozano-Montoya and Denis O{\textquoteright}Mahony and Soiza, {Roy L.} and Marjolein Visser and Dorothee Volkert and Maike Wolters and Jentoft, {Alfonso J. Cruz}",

note = "The preparation of this paper was supported by the MalNutrition in the ELderly (MaNuEL) knowledge hub. MaNuEL is supported by the Joint Programming Initiative {\textquoteleft}Healthy Diet for a Healthy Life{\textquoteright}. The MaNuEL funding agencies supporting this paper are (in alphabetical order of participating Member State): France: Ecole Sup{\'e}rieure d{\textquoteright}Agricultires (ESA); Germany: Federal Ministry of Food and Agriculture (BMEL) represented by Federal Office for Agriculture and Food (BLE); The Netherlands: The Netherlands Organisation for Health Research and Development (ZonMw). This work was also supported by the SENATOR trial (FP7-HEALTH-2012-305930).",

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doi = "10.1016/j.arr.2018.10.011",

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T1 - Efficacy of non-pharmacological interventions to treat malnutrition in older persons

T2 - A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

AU - Correa-Pérez, Andrea

AU - Abraha, Iosef

AU - Cherubini, Antonio

AU - Collinson, Avril

AU - Dardevet, Dominique

AU - de Groot, Lisette CPGM

AU - de van der Schueren, Marian A.E.

AU - Hebestreit, Antje

AU - Hickson, Mary

AU - Jaramillo-Hidalgo, Javier

AU - Lozano-Montoya, Isabel

AU - O’Mahony, Denis

AU - Soiza, Roy L.

AU - Visser, Marjolein

AU - Volkert, Dorothee

AU - Wolters, Maike

AU - Jentoft, Alfonso J. Cruz

N1 - The preparation of this paper was supported by the MalNutrition in the ELderly (MaNuEL) knowledge hub. MaNuEL is supported by the Joint Programming Initiative ‘Healthy Diet for a Healthy Life’. The MaNuEL funding agencies supporting this paper are (in alphabetical order of participating Member State): France: Ecole Supérieure d’Agricultires (ESA); Germany: Federal Ministry of Food and Agriculture (BMEL) represented by Federal Office for Agriculture and Food (BLE); The Netherlands: The Netherlands Organisation for Health Research and Development (ZonMw). This work was also supported by the SENATOR trial (FP7-HEALTH-2012-305930).

PY - 2019/1

Y1 - 2019/1

N2 - INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.

AB - INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.

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KW - Protein energy malnutrition

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Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

Abstract

Bibliographical note

Keywords

UN SDGs

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Roy Soiza

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Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Profiles

Roy Soiza

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