Efficacy of non-pharmacological interventions to treat malnutrition in older persons

A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

Andrea Correa-Pérez (Corresponding Author), Iosef Abraha, Antonio Cherubini, Avril Collinson, Dominique Dardevet, Lisette CPGM de Groot, Marian A.E. de van der Schueren, Antje Hebestreit, Mary Hickson, Javier Jaramillo-Hidalgo, Isabel Lozano-Montoya, Denis O’Mahony, Roy L. Soiza, Marjolein Visser, Dorothee Volkert, Maike Wolters, Alfonso J. Cruz Jentoft

Research output: Contribution to journalArticle

Abstract

INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.
Original languageEnglish
Pages (from-to)27-48
Number of pages22
JournalAgeing Research Reviews
Volume49
Early online date2 Nov 2018
DOIs
Publication statusPublished - Jan 2019

Fingerprint

Malnutrition
Meta-Analysis
Body Weight Changes
Muscle Strength
Activities of Daily Living
Nutrition
PubMed
Sample Size
Muscle
Counseling
Body Mass Index
Quality of Life
Databases
Exercise
Mortality
Research
Therapeutics

Keywords

  • protein energy malnutrition
  • elderly
  • review
  • dietary supplementation
  • systematic
  • Elderly, dietary supplementation
  • Review, systematic
  • Protein energy malnutrition

ASJC Scopus subject areas

  • Neurology
  • Ageing
  • Molecular Biology
  • Biochemistry
  • Biotechnology

Cite this

Efficacy of non-pharmacological interventions to treat malnutrition in older persons : A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project. / Correa-Pérez, Andrea (Corresponding Author); Abraha, Iosef; Cherubini, Antonio; Collinson, Avril; Dardevet, Dominique; de Groot, Lisette CPGM; de van der Schueren, Marian A.E.; Hebestreit, Antje; Hickson, Mary; Jaramillo-Hidalgo, Javier; Lozano-Montoya, Isabel; O’Mahony, Denis; Soiza, Roy L.; Visser, Marjolein; Volkert, Dorothee; Wolters, Maike; Jentoft, Alfonso J. Cruz.

In: Ageing Research Reviews, Vol. 49, 01.2019, p. 27-48.

Research output: Contribution to journalArticle

Correa-Pérez, A, Abraha, I, Cherubini, A, Collinson, A, Dardevet, D, de Groot, LCPGM, de van der Schueren, MAE, Hebestreit, A, Hickson, M, Jaramillo-Hidalgo, J, Lozano-Montoya, I, O’Mahony, D, Soiza, RL, Visser, M, Volkert, D, Wolters, M & Jentoft, AJC 2019, 'Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project', Ageing Research Reviews, vol. 49, pp. 27-48. https://doi.org/10.1016/j.arr.2018.10.011
Correa-Pérez, Andrea ; Abraha, Iosef ; Cherubini, Antonio ; Collinson, Avril ; Dardevet, Dominique ; de Groot, Lisette CPGM ; de van der Schueren, Marian A.E. ; Hebestreit, Antje ; Hickson, Mary ; Jaramillo-Hidalgo, Javier ; Lozano-Montoya, Isabel ; O’Mahony, Denis ; Soiza, Roy L. ; Visser, Marjolein ; Volkert, Dorothee ; Wolters, Maike ; Jentoft, Alfonso J. Cruz. / Efficacy of non-pharmacological interventions to treat malnutrition in older persons : A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project. In: Ageing Research Reviews. 2019 ; Vol. 49. pp. 27-48.
@article{98bbdbeada4749d0acba4c0042aa4fcf,
title = "Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project",
abstract = "INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95{\%}CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95{\%}CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.",
keywords = "protein energy malnutrition, elderly, review, dietary supplementation, systematic, Elderly, dietary supplementation, Review, systematic, Protein energy malnutrition",
author = "Andrea Correa-P{\'e}rez and Iosef Abraha and Antonio Cherubini and Avril Collinson and Dominique Dardevet and {de Groot}, {Lisette CPGM} and {de van der Schueren}, {Marian A.E.} and Antje Hebestreit and Mary Hickson and Javier Jaramillo-Hidalgo and Isabel Lozano-Montoya and Denis O’Mahony and Soiza, {Roy L.} and Marjolein Visser and Dorothee Volkert and Maike Wolters and Jentoft, {Alfonso J. Cruz}",
note = "The preparation of this paper was supported by the MalNutrition in the ELderly (MaNuEL) knowledge hub. MaNuEL is supported by the Joint Programming Initiative ‘Healthy Diet for a Healthy Life’. The MaNuEL funding agencies supporting this paper are (in alphabetical order of participating Member State): France: Ecole Sup{\'e}rieure d’Agricultires (ESA); Germany: Federal Ministry of Food and Agriculture (BMEL) represented by Federal Office for Agriculture and Food (BLE); The Netherlands: The Netherlands Organisation for Health Research and Development (ZonMw). This work was also supported by the SENATOR trial (FP7-HEALTH-2012-305930).",
year = "2019",
month = "1",
doi = "10.1016/j.arr.2018.10.011",
language = "English",
volume = "49",
pages = "27--48",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Efficacy of non-pharmacological interventions to treat malnutrition in older persons

T2 - A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project

AU - Correa-Pérez, Andrea

AU - Abraha, Iosef

AU - Cherubini, Antonio

AU - Collinson, Avril

AU - Dardevet, Dominique

AU - de Groot, Lisette CPGM

AU - de van der Schueren, Marian A.E.

AU - Hebestreit, Antje

AU - Hickson, Mary

AU - Jaramillo-Hidalgo, Javier

AU - Lozano-Montoya, Isabel

AU - O’Mahony, Denis

AU - Soiza, Roy L.

AU - Visser, Marjolein

AU - Volkert, Dorothee

AU - Wolters, Maike

AU - Jentoft, Alfonso J. Cruz

N1 - The preparation of this paper was supported by the MalNutrition in the ELderly (MaNuEL) knowledge hub. MaNuEL is supported by the Joint Programming Initiative ‘Healthy Diet for a Healthy Life’. The MaNuEL funding agencies supporting this paper are (in alphabetical order of participating Member State): France: Ecole Supérieure d’Agricultires (ESA); Germany: Federal Ministry of Food and Agriculture (BMEL) represented by Federal Office for Agriculture and Food (BLE); The Netherlands: The Netherlands Organisation for Health Research and Development (ZonMw). This work was also supported by the SENATOR trial (FP7-HEALTH-2012-305930).

PY - 2019/1

Y1 - 2019/1

N2 - INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.

AB - INTRODUCTION We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.

KW - protein energy malnutrition

KW - elderly

KW - review

KW - dietary supplementation

KW - systematic

KW - Elderly, dietary supplementation

KW - Review, systematic

KW - Protein energy malnutrition

UR - http://www.scopus.com/inward/record.url?scp=85057001025&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/efficacy-nonpharmacological-interventions-treat-malnutrition-older-persons-systematic-review-metaana

U2 - 10.1016/j.arr.2018.10.011

DO - 10.1016/j.arr.2018.10.011

M3 - Article

VL - 49

SP - 27

EP - 48

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

ER -