Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain

Daniel A. Berg, Matthew Kirkham, Anna Beljajeva, Dunja Knapp, Bianca Habermann, Jesper Ryge, Elly M. Tanaka, András Simon*

*Corresponding author for this work

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

In contrast to mammals, salamanders and teleost fishes can efficiently repair the adult brain. It has been hypothesised that constitutively active neurogenic niches are a prerequisite for extensive neuronal regeneration capacity. Here, we show that the highly regenerative salamander, the red spotted newt, displays an unexpectedly similar distribution of active germinal niches with mammals under normal physiological conditions. Proliferation zones in the adult newt brain are restricted to the forebrain, whereas all other regions are essentially quiescent. However, ablation of midbrain dopamine neurons in newts induced ependymoglia cells in the normally quiescent midbrain to proliferate and to undertake full dopamine neuron regeneration. Using oligonucleotide microarrays, we have catalogued a set of differentially expressed genes in these activated ependymoglia cells. This strategy identified hedgehog signalling as a key component of adult dopamine neuron regeneration. These data show that brain regeneration can occur by activation of neurogenesis in quiescent brain regions.

Original languageEnglish
Pages (from-to)4127-4134
Number of pages8
JournalDevelopment
Volume137
Issue number24
DOIs
Publication statusPublished - 15 Dec 2010

Keywords

  • 6-OHDA
  • Adult neurogenesis
  • Dopamine
  • Midbrain
  • Neuronal stem cell
  • Salamander

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    Berg, D. A., Kirkham, M., Beljajeva, A., Knapp, D., Habermann, B., Ryge, J., Tanaka, E. M., & Simon, A. (2010). Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain. Development, 137(24), 4127-4134. https://doi.org/10.1242/dev.055541