Elevated titres of anti-human heat shock protein 60 predict an adverse one year prognosis in patients with acute chest pain

D. Birnie, L. Vickers, John David Norrie, S. M. Cobbe

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    Abstract

    Objective: To assess whether antibodies to human heat shock protein 60 (anti-huhsp60) or to mycobacterial heat shock protein 65 (anti-mhsp65) predict an adverse one year prognosis in patients admitted with acute cardiac chest pain.

    Design: Prospective observational study.

    Setting: Teaching hospital.

    Patients: 588 consecutive emergency admissions of patients with acute chest pain of suspected cardiac origin.

    Main outcome measures: Anti-huhsp60 and anti-mhsp65 titres were assayed on samples drawn on the morning after admission. The end points after discharge were coronary heart disease death, non-fatal myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, angiogram, or readmission with further cardiac ischaemic chest pain.

    Results: During follow up after discharge (mean of 304 days, range 1-788 days), 277 patients had at least one of the study outcomes. Patients with increased titres of anti-huhsp60 had an adverse prognosis (hazard ratio 1.56 (95% confidence interval 1.09 to 2.23) comparing highest versus lowest quartiles, p = 0.015). Anti-mhsp65 titres were not predictive.

    Conclusions: Patients admitted with acute cardiac chest pain and increased titres of anti-huhsp60 had an adverse one year prognosis.

    Original languageEnglish
    Pages (from-to)1148-1153
    Number of pages5
    JournalHeart
    Volume91
    Issue number9
    DOIs
    Publication statusPublished - 2005

    Keywords

    • HEAT-SHOCK-PROTEIN
    • CORONARY-ARTERY DISEASE
    • C-REACTIVE PROTEIN
    • CHLAMYDIA-PNEUMONIAE INFECTION
    • CAROTID ATHEROSCLEROSIS
    • SERUM ANTIBODIES
    • HUMAN HEAT-SHOCK-PROTEIN-60
    • CARDIOVASCULAR-DISEASE
    • ENDOTHELIAL-CELLS
    • ASPIRIN

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