Elevated titres of anti-human heat shock protein 60 predict an adverse one year prognosis in patients with acute chest pain

D. Birnie, L. Vickers, John David Norrie, S. M. Cobbe

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Objective: To assess whether antibodies to human heat shock protein 60 (anti-huhsp60) or to mycobacterial heat shock protein 65 (anti-mhsp65) predict an adverse one year prognosis in patients admitted with acute cardiac chest pain.

    Design: Prospective observational study.

    Setting: Teaching hospital.

    Patients: 588 consecutive emergency admissions of patients with acute chest pain of suspected cardiac origin.

    Main outcome measures: Anti-huhsp60 and anti-mhsp65 titres were assayed on samples drawn on the morning after admission. The end points after discharge were coronary heart disease death, non-fatal myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, angiogram, or readmission with further cardiac ischaemic chest pain.

    Results: During follow up after discharge (mean of 304 days, range 1-788 days), 277 patients had at least one of the study outcomes. Patients with increased titres of anti-huhsp60 had an adverse prognosis (hazard ratio 1.56 (95% confidence interval 1.09 to 2.23) comparing highest versus lowest quartiles, p = 0.015). Anti-mhsp65 titres were not predictive.

    Conclusions: Patients admitted with acute cardiac chest pain and increased titres of anti-huhsp60 had an adverse one year prognosis.

    Original languageEnglish
    Pages (from-to)1148-1153
    Number of pages5
    JournalHeart
    Volume91
    Issue number9
    DOIs
    Publication statusPublished - 2005

    Keywords

    • HEAT-SHOCK-PROTEIN
    • CORONARY-ARTERY DISEASE
    • C-REACTIVE PROTEIN
    • CHLAMYDIA-PNEUMONIAE INFECTION
    • CAROTID ATHEROSCLEROSIS
    • SERUM ANTIBODIES
    • HUMAN HEAT-SHOCK-PROTEIN-60
    • CARDIOVASCULAR-DISEASE
    • ENDOTHELIAL-CELLS
    • ASPIRIN

    Cite this

    Elevated titres of anti-human heat shock protein 60 predict an adverse one year prognosis in patients with acute chest pain. / Birnie, D.; Vickers, L.; Norrie, John David; Cobbe, S. M.

    In: Heart, Vol. 91, No. 9, 2005, p. 1148-1153.

    Research output: Contribution to journalArticle

    Birnie, D. ; Vickers, L. ; Norrie, John David ; Cobbe, S. M. / Elevated titres of anti-human heat shock protein 60 predict an adverse one year prognosis in patients with acute chest pain. In: Heart. 2005 ; Vol. 91, No. 9. pp. 1148-1153.
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    abstract = "Objective: To assess whether antibodies to human heat shock protein 60 (anti-huhsp60) or to mycobacterial heat shock protein 65 (anti-mhsp65) predict an adverse one year prognosis in patients admitted with acute cardiac chest pain.Design: Prospective observational study.Setting: Teaching hospital.Patients: 588 consecutive emergency admissions of patients with acute chest pain of suspected cardiac origin.Main outcome measures: Anti-huhsp60 and anti-mhsp65 titres were assayed on samples drawn on the morning after admission. The end points after discharge were coronary heart disease death, non-fatal myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, angiogram, or readmission with further cardiac ischaemic chest pain.Results: During follow up after discharge (mean of 304 days, range 1-788 days), 277 patients had at least one of the study outcomes. Patients with increased titres of anti-huhsp60 had an adverse prognosis (hazard ratio 1.56 (95{\%} confidence interval 1.09 to 2.23) comparing highest versus lowest quartiles, p = 0.015). Anti-mhsp65 titres were not predictive.Conclusions: Patients admitted with acute cardiac chest pain and increased titres of anti-huhsp60 had an adverse one year prognosis.",
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    PY - 2005

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    N2 - Objective: To assess whether antibodies to human heat shock protein 60 (anti-huhsp60) or to mycobacterial heat shock protein 65 (anti-mhsp65) predict an adverse one year prognosis in patients admitted with acute cardiac chest pain.Design: Prospective observational study.Setting: Teaching hospital.Patients: 588 consecutive emergency admissions of patients with acute chest pain of suspected cardiac origin.Main outcome measures: Anti-huhsp60 and anti-mhsp65 titres were assayed on samples drawn on the morning after admission. The end points after discharge were coronary heart disease death, non-fatal myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, angiogram, or readmission with further cardiac ischaemic chest pain.Results: During follow up after discharge (mean of 304 days, range 1-788 days), 277 patients had at least one of the study outcomes. Patients with increased titres of anti-huhsp60 had an adverse prognosis (hazard ratio 1.56 (95% confidence interval 1.09 to 2.23) comparing highest versus lowest quartiles, p = 0.015). Anti-mhsp65 titres were not predictive.Conclusions: Patients admitted with acute cardiac chest pain and increased titres of anti-huhsp60 had an adverse one year prognosis.

    AB - Objective: To assess whether antibodies to human heat shock protein 60 (anti-huhsp60) or to mycobacterial heat shock protein 65 (anti-mhsp65) predict an adverse one year prognosis in patients admitted with acute cardiac chest pain.Design: Prospective observational study.Setting: Teaching hospital.Patients: 588 consecutive emergency admissions of patients with acute chest pain of suspected cardiac origin.Main outcome measures: Anti-huhsp60 and anti-mhsp65 titres were assayed on samples drawn on the morning after admission. The end points after discharge were coronary heart disease death, non-fatal myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, angiogram, or readmission with further cardiac ischaemic chest pain.Results: During follow up after discharge (mean of 304 days, range 1-788 days), 277 patients had at least one of the study outcomes. Patients with increased titres of anti-huhsp60 had an adverse prognosis (hazard ratio 1.56 (95% confidence interval 1.09 to 2.23) comparing highest versus lowest quartiles, p = 0.015). Anti-mhsp65 titres were not predictive.Conclusions: Patients admitted with acute cardiac chest pain and increased titres of anti-huhsp60 had an adverse one year prognosis.

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    KW - SERUM ANTIBODIES

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    KW - CARDIOVASCULAR-DISEASE

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