Abstract
The first experimental application of enantioselective Raman spectroscopy (esR) is demonstrated using the example of the chiral alcohol 2-butanol. Samples of the neat enantiomers and the racemic mixture were analyzed in a self-built Raman set-up. The Raman spectrum allows the discrimination of the chemical species. It is shown that the optical rotation of a Raman peak with a small depolarization ratio can be measured. In addition, without any sample modification, e.g. chiral solvent, the enantiomers are distinguishable at a suitable half-wave retarder angle detecting only the vertically polarized component of the Raman signal.
Original language | English |
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Pages (from-to) | 3040-3048 |
Number of pages | 9 |
Journal | Analyst |
Volume | 143 |
Issue number | 13 |
Early online date | 16 May 2018 |
DOIs | |
Publication status | Published - 7 Jul 2018 |
Keywords
- VIBRATIONAL CIRCULAR-DICHROISM
- OPTICAL-ACTIVITY SPECTROSCOPY
- HYDROGEN-BONDED COMPLEXES
- CHIRAL MOLECULES
- ABSOLUTE-CONFIGURATIONS
- MICROWAVE SPECTROSCOPY
- DISCRIMINATION
- SCATTERING
- ALCOHOLS
- SPECTRA