Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism

A V Krylatov, R V Uzhachenko, L N Maslov, N A Bernatskaya, A Makriyannis, R Mechoulam, R G Pertwee, O M Sal'nikova, J B Stefano, Y B Lishmanov

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Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with N-G-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Publication statusPublished - 2002


  • cannabinoid receptors
  • arrhythmias
  • endogenous cannabinoids

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