Abstract
Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with N-G-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.
Original language | English |
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Pages (from-to) | 122-124 |
Number of pages | 3 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 133 |
Publication status | Published - 2002 |
Keywords
- cannabinoid receptors
- arrhythmias
- endogenous cannabinoids
- ARRHYTHMIAS
- ANANDAMIDE
- HEART