Abstract
Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.
| Original language | English |
|---|---|
| Pages (from-to) | 184-190 |
| Number of pages | 7 |
| Journal | EMBO reports |
| Volume | 14 |
| Issue number | 2 |
| Early online date | 18 Jan 2013 |
| DOIs | |
| Publication status | Published - Feb 2013 |
Keywords
- animals
- cell movement
- cerebral ventricles
- electric impedance
- electric stimulation
- electrodes
- gene knockdown techniques
- mice
- neural stem cells
- olfactory bulb
- purinergic P2Y receptor antagonists
- RNA, small interfering
- receptors, purinergic P2Y1
- suramin
- neuroblast
- rostral migration
- electric field
- electrical corridors
- purinergic receptor