Endogenous electric currents might guide rostral migration of neuroblasts

Lin Cao, Dongguang Wei, Brian Reid, Siwei Zhao, Jin Pu, Tingrui Pan, Ebenezer Yamoah, Min Zhao

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.
Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalEMBO reports
Volume14
Issue number2
Early online date18 Jan 2013
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Lateral Ventricles
Electric currents
Purinergic P2Y1 Receptors
Brain
Cues
Electric fields

Keywords

  • animals
  • cell movement
  • cerebral ventricles
  • electric impedance
  • electric stimulation
  • electrodes
  • gene knockdown techniques
  • mice
  • neural stem cells
  • olfactory bulb
  • purinergic P2Y receptor antagonists
  • RNA, small interfering
  • receptors, purinergic P2Y1
  • suramin
  • neuroblast
  • rostral migration
  • electric field
  • electrical corridors
  • purinergic receptor

Cite this

Endogenous electric currents might guide rostral migration of neuroblasts. / Cao, Lin; Wei, Dongguang; Reid, Brian; Zhao, Siwei; Pu, Jin; Pan, Tingrui; Yamoah, Ebenezer; Zhao, Min.

In: EMBO reports, Vol. 14, No. 2, 02.2013, p. 184-190.

Research output: Contribution to journalArticle

Cao, Lin ; Wei, Dongguang ; Reid, Brian ; Zhao, Siwei ; Pu, Jin ; Pan, Tingrui ; Yamoah, Ebenezer ; Zhao, Min. / Endogenous electric currents might guide rostral migration of neuroblasts. In: EMBO reports. 2013 ; Vol. 14, No. 2. pp. 184-190.
@article{9a79fee460f44e24a5e3bb523d53964b,
title = "Endogenous electric currents might guide rostral migration of neuroblasts",
abstract = "Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.",
keywords = "animals, cell movement, cerebral ventricles, electric impedance, electric stimulation, electrodes, gene knockdown techniques, mice, neural stem cells, olfactory bulb, purinergic P2Y receptor antagonists, RNA, small interfering, receptors, purinergic P2Y1, suramin, neuroblast, rostral migration, electric field, electrical corridors, purinergic receptor",
author = "Lin Cao and Dongguang Wei and Brian Reid and Siwei Zhao and Jin Pu and Tingrui Pan and Ebenezer Yamoah and Min Zhao",
year = "2013",
month = "2",
doi = "10.1038/embor.2012.215",
language = "English",
volume = "14",
pages = "184--190",
journal = "EMBO reports",
issn = "1469-221X",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Endogenous electric currents might guide rostral migration of neuroblasts

AU - Cao, Lin

AU - Wei, Dongguang

AU - Reid, Brian

AU - Zhao, Siwei

AU - Pu, Jin

AU - Pan, Tingrui

AU - Yamoah, Ebenezer

AU - Zhao, Min

PY - 2013/2

Y1 - 2013/2

N2 - Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.

AB - Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.

KW - animals

KW - cell movement

KW - cerebral ventricles

KW - electric impedance

KW - electric stimulation

KW - electrodes

KW - gene knockdown techniques

KW - mice

KW - neural stem cells

KW - olfactory bulb

KW - purinergic P2Y receptor antagonists

KW - RNA, small interfering

KW - receptors, purinergic P2Y1

KW - suramin

KW - neuroblast

KW - rostral migration

KW - electric field

KW - electrical corridors

KW - purinergic receptor

U2 - 10.1038/embor.2012.215

DO - 10.1038/embor.2012.215

M3 - Article

VL - 14

SP - 184

EP - 190

JO - EMBO reports

JF - EMBO reports

SN - 1469-221X

IS - 2

ER -