TY - JOUR
T1 - Endoscopic full thickness resection in the colo-rectum
T2 - Outcomes from the UK Registry
AU - Boger, Philip
AU - Rahman, Imdadur
AU - Hu, Maxworth
AU - Ayaru, Laksh
AU - Bhandari, Pradeep
AU - Chedgy, Fergus
AU - Green, Susi
AU - Hayat, Mumtaz
AU - Hopper, Andrew D.
AU - Ishaq, Sauid
AU - Martin, John
AU - McCallum, Iain
AU - Phull, Perminder
AU - Pugh, Stirling
AU - Russo, Evangelos
AU - Suzuki, Noriko
AU - Thomas-Gibson, Siwan
AU - Zeino, Zeino
AU - Patel, Praful
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Background Endoscopic full-thickness resection (eFTR) of the colon using the full-thickness resection device (FTRD) is a novel method for removing lesions involving, or tethered to, deeper layers of the colonic wall. The UK FTRD Registry collected data from multiple centres performing this procedure. We describe the technical feasibility, safety and early outcomes of this technique in the UK. Methods Data were collected and analysed on 68 patients who underwent eFTR at 11 UK centres from April 2015 to June 2019. Outcome measures were technical success, procedural time, specimen size, R0 resection, endoscopic clearance, and adverse events. Reported technical difficulties were collated. Results Indications for eFTR included non-lifting polyps (29 cases), T1 tumour resection (13), subepithelial tumour (9), and polyps at the appendix base or diverticulum (17). Target lesion resection was achieved in 60/68 (88.2%). Median specimen size was 21.7 mm (10-35 mm). Histologically confirmed R0 resection was achieved in 43/56 (76.8%) with full-thickness resection in 52/56 (92.9%). Technical difficulties occurred in 17/68 (25%) and complications in 3/68 (5.9%) patients. Conclusion eFTR is a useful technique with a high success rate in treating lesions not previously amenable to endoscopic therapy. Whilst technical difficulties may arise, complication rates are low and outcomes are acceptable, making eFTR a viable alternative to surgery for some specific lesions.
AB - Background Endoscopic full-thickness resection (eFTR) of the colon using the full-thickness resection device (FTRD) is a novel method for removing lesions involving, or tethered to, deeper layers of the colonic wall. The UK FTRD Registry collected data from multiple centres performing this procedure. We describe the technical feasibility, safety and early outcomes of this technique in the UK. Methods Data were collected and analysed on 68 patients who underwent eFTR at 11 UK centres from April 2015 to June 2019. Outcome measures were technical success, procedural time, specimen size, R0 resection, endoscopic clearance, and adverse events. Reported technical difficulties were collated. Results Indications for eFTR included non-lifting polyps (29 cases), T1 tumour resection (13), subepithelial tumour (9), and polyps at the appendix base or diverticulum (17). Target lesion resection was achieved in 60/68 (88.2%). Median specimen size was 21.7 mm (10-35 mm). Histologically confirmed R0 resection was achieved in 43/56 (76.8%) with full-thickness resection in 52/56 (92.9%). Technical difficulties occurred in 17/68 (25%) and complications in 3/68 (5.9%) patients. Conclusion eFTR is a useful technique with a high success rate in treating lesions not previously amenable to endoscopic therapy. Whilst technical difficulties may arise, complication rates are low and outcomes are acceptable, making eFTR a viable alternative to surgery for some specific lesions.
KW - colo-rectum
KW - endoscopic full-thickness resection
KW - full-thickness resection device
KW - neoplasms
KW - polyps
KW - subepithelial tumour
UR - http://www.scopus.com/inward/record.url?scp=85105560457&partnerID=8YFLogxK
U2 - 10.1097/MEG.0000000000001987
DO - 10.1097/MEG.0000000000001987
M3 - Article
C2 - 33136721
AN - SCOPUS:85105560457
SN - 0954-691X
VL - 33
SP - 852
EP - 858
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 6
ER -