Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

Andrew Shaw, Mary K Doherty, Nicola J Mutch, Sandra M MacRury, Ian L Megson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Atherothrombotic disease is a well-recognized complication of diabetes and is a major contributor to the high morbidity and mortality associated with diabetes. Although there is substantial evidence linking diabetes with cardiovascular disease, the specific effect of hyper- (or hypo-) glycaemia is less well understood. The present review focuses on the impact that glycaemic dysregulation has on respiratory function and ROS (reactive oxygen species) generation in the endothelial cells that are critical in preventing several key steps in the atherothrombotic process. Endothelial cells are particularly susceptible to ROS-mediated dysfunction not only because of reduced cell viability and increased senescence, but also because one of the major endothelium-derived factors that help to protect against atherosclerosis, nitric oxide, is rapidly deactivated by superoxide radicals.

Original languageEnglish
Pages (from-to)928-933
Number of pages6
JournalBiochemical Society Transactions
Volume42
Issue number4
DOIs
Publication statusPublished - 1 Aug 2014

Fingerprint

Oxidative stress
Endothelial cells
Medical problems
Reactive Oxygen Species
Oxidative Stress
Endothelial Cells
Diabetes Complications
Superoxides
Endothelium
Cell Survival
Atherosclerosis
Nitric Oxide
Cardiovascular Diseases
Morbidity
Mortality
Cells

Keywords

  • cardiovascular disease
  • diabetes
  • endothelial cell
  • glucose
  • oxidative stress

Cite this

Endothelial cell oxidative stress in diabetes : a key driver of cardiovascular complications? / Shaw, Andrew; Doherty, Mary K; Mutch, Nicola J; MacRury, Sandra M; Megson, Ian L.

In: Biochemical Society Transactions, Vol. 42, No. 4, 01.08.2014, p. 928-933.

Research output: Contribution to journalArticle

Shaw, Andrew ; Doherty, Mary K ; Mutch, Nicola J ; MacRury, Sandra M ; Megson, Ian L. / Endothelial cell oxidative stress in diabetes : a key driver of cardiovascular complications?. In: Biochemical Society Transactions. 2014 ; Vol. 42, No. 4. pp. 928-933.
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