Engineering immunity in the mammary gland

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    The major physiological function of milk is the transport of amino acids, carbohydrates, lipids, and minerals to mammalian offspring. However, milk is also a rich collection of antimicrobial substances, which provide protection against pathogenic infections. These molecules safeguard the integrity of the lactating mammary gland, but also provide protection for the suckling offspring during a time when its immune system is still immature. The protective substances can be classified into two categories: 1) nonspecific defense substances, which provide innate immunity, and 2) molecules such as antibodies, which provide adaptive immunity and are directed against specific pathogens. The antimicrobial potency of milk has not been a target for farm animal breeding in the past, and present day ruminants provide suboptimal levels of antimicrobial substances in milk. Altered breeding regimes, pharmacological intervention, and transgenesis can be utilized to improve the antimicrobial properties of milk. Such alterations of milk composition have implications for human and animal health.

    Original languageEnglish
    Pages (from-to)123-134
    Number of pages12
    JournalJournal of Mammary Gland Biology and Neoplasia
    Volume7
    Issue number2
    DOIs
    Publication statusPublished - Apr 2002

    Keywords

    • milk
    • immunology
    • pathogen
    • protection
    • neutralization
    • respiratory syncytial virus
    • fully human-antibodies
    • transgenic mice
    • bovine lactoferrin
    • antimicrobial properties
    • epithelial-cells
    • human lysozyme
    • FC receptor
    • expression

    Cite this

    Engineering immunity in the mammary gland. / Kolb, Andreas.

    In: Journal of Mammary Gland Biology and Neoplasia, Vol. 7, No. 2, 04.2002, p. 123-134.

    Research output: Contribution to journalArticle

    @article{29c5187031894ba59dca93e804317bb5,
    title = "Engineering immunity in the mammary gland",
    abstract = "The major physiological function of milk is the transport of amino acids, carbohydrates, lipids, and minerals to mammalian offspring. However, milk is also a rich collection of antimicrobial substances, which provide protection against pathogenic infections. These molecules safeguard the integrity of the lactating mammary gland, but also provide protection for the suckling offspring during a time when its immune system is still immature. The protective substances can be classified into two categories: 1) nonspecific defense substances, which provide innate immunity, and 2) molecules such as antibodies, which provide adaptive immunity and are directed against specific pathogens. The antimicrobial potency of milk has not been a target for farm animal breeding in the past, and present day ruminants provide suboptimal levels of antimicrobial substances in milk. Altered breeding regimes, pharmacological intervention, and transgenesis can be utilized to improve the antimicrobial properties of milk. Such alterations of milk composition have implications for human and animal health.",
    keywords = "milk, immunology, pathogen, protection, neutralization, respiratory syncytial virus, fully human-antibodies, transgenic mice, bovine lactoferrin, antimicrobial properties, epithelial-cells, human lysozyme, FC receptor, expression",
    author = "Andreas Kolb",
    year = "2002",
    month = "4",
    doi = "10.1023/A:1020395701887",
    language = "English",
    volume = "7",
    pages = "123--134",
    journal = "Journal of Mammary Gland Biology and Neoplasia",
    issn = "1083-3021",
    publisher = "Springer New York",
    number = "2",

    }

    TY - JOUR

    T1 - Engineering immunity in the mammary gland

    AU - Kolb, Andreas

    PY - 2002/4

    Y1 - 2002/4

    N2 - The major physiological function of milk is the transport of amino acids, carbohydrates, lipids, and minerals to mammalian offspring. However, milk is also a rich collection of antimicrobial substances, which provide protection against pathogenic infections. These molecules safeguard the integrity of the lactating mammary gland, but also provide protection for the suckling offspring during a time when its immune system is still immature. The protective substances can be classified into two categories: 1) nonspecific defense substances, which provide innate immunity, and 2) molecules such as antibodies, which provide adaptive immunity and are directed against specific pathogens. The antimicrobial potency of milk has not been a target for farm animal breeding in the past, and present day ruminants provide suboptimal levels of antimicrobial substances in milk. Altered breeding regimes, pharmacological intervention, and transgenesis can be utilized to improve the antimicrobial properties of milk. Such alterations of milk composition have implications for human and animal health.

    AB - The major physiological function of milk is the transport of amino acids, carbohydrates, lipids, and minerals to mammalian offspring. However, milk is also a rich collection of antimicrobial substances, which provide protection against pathogenic infections. These molecules safeguard the integrity of the lactating mammary gland, but also provide protection for the suckling offspring during a time when its immune system is still immature. The protective substances can be classified into two categories: 1) nonspecific defense substances, which provide innate immunity, and 2) molecules such as antibodies, which provide adaptive immunity and are directed against specific pathogens. The antimicrobial potency of milk has not been a target for farm animal breeding in the past, and present day ruminants provide suboptimal levels of antimicrobial substances in milk. Altered breeding regimes, pharmacological intervention, and transgenesis can be utilized to improve the antimicrobial properties of milk. Such alterations of milk composition have implications for human and animal health.

    KW - milk

    KW - immunology

    KW - pathogen

    KW - protection

    KW - neutralization

    KW - respiratory syncytial virus

    KW - fully human-antibodies

    KW - transgenic mice

    KW - bovine lactoferrin

    KW - antimicrobial properties

    KW - epithelial-cells

    KW - human lysozyme

    KW - FC receptor

    KW - expression

    U2 - 10.1023/A:1020395701887

    DO - 10.1023/A:1020395701887

    M3 - Article

    VL - 7

    SP - 123

    EP - 134

    JO - Journal of Mammary Gland Biology and Neoplasia

    JF - Journal of Mammary Gland Biology and Neoplasia

    SN - 1083-3021

    IS - 2

    ER -