Environmental risk factors in systemic sclerosis

Paula Dospinescu, Gareth T. Jones, Neil Basu*

*Corresponding author for this work

Research output: Contribution to journalLiterature review

15 Citations (Scopus)

Abstract

Purpose of review

Environmental risk factors have been implicated in the pathogenesis of systemic sclerosis (SSc). Recent evidence further supports this relationship and constitutes the focus of this review article.

Recent findings

Exposure to silica through various occupations remains one of the main environmental risk factors for SSc. Emerging evidence has also implicated organic solvents in the development of this difficult-to-manage condition. The individual role of these toxins is, however, difficult to ascertain due to methodological limitations in study design. Other occupational agents, such as epoxy resins, welding fumes and hand-arm vibration, have been investigated, but no definitive associations may be made due to small sample sizes. The controversial association between silicone breast surgery and SSc has not been proven and, amongst other non-occupational factors, smoking does not increase the risk of development but does appear to impact upon the severity of disease.

Summary

A number of environmental exposures are likely to play an important role in the development of the disease; however, current evidence consists mainly of heterogeneous studies with relatively small sample sizes. In the future, multicentre collaborations may help inform preventive strategies.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalCurrent Opinion in Rheumatology
Volume25
Issue number2
DOIs
Publication statusPublished - Mar 2013

Keywords

  • systemic sclerosis
  • scleroderma
  • Raynauds-phenomenon
  • survival
  • epidemiology
  • metaanalysis
  • autoimmune-disease
  • solvents
  • silica
  • occupational silica exposure
  • cigarette-smoking
  • prevalence
  • solvent exposure

Cite this

Environmental risk factors in systemic sclerosis. / Dospinescu, Paula; Jones, Gareth T.; Basu, Neil.

In: Current Opinion in Rheumatology, Vol. 25, No. 2, 03.2013, p. 179-183.

Research output: Contribution to journalLiterature review

Dospinescu, Paula ; Jones, Gareth T. ; Basu, Neil. / Environmental risk factors in systemic sclerosis. In: Current Opinion in Rheumatology. 2013 ; Vol. 25, No. 2. pp. 179-183.
@article{5210f5eece314ccfba6658a57869e224,
title = "Environmental risk factors in systemic sclerosis",
abstract = "Purpose of reviewEnvironmental risk factors have been implicated in the pathogenesis of systemic sclerosis (SSc). Recent evidence further supports this relationship and constitutes the focus of this review article.Recent findingsExposure to silica through various occupations remains one of the main environmental risk factors for SSc. Emerging evidence has also implicated organic solvents in the development of this difficult-to-manage condition. The individual role of these toxins is, however, difficult to ascertain due to methodological limitations in study design. Other occupational agents, such as epoxy resins, welding fumes and hand-arm vibration, have been investigated, but no definitive associations may be made due to small sample sizes. The controversial association between silicone breast surgery and SSc has not been proven and, amongst other non-occupational factors, smoking does not increase the risk of development but does appear to impact upon the severity of disease.SummaryA number of environmental exposures are likely to play an important role in the development of the disease; however, current evidence consists mainly of heterogeneous studies with relatively small sample sizes. In the future, multicentre collaborations may help inform preventive strategies.",
keywords = "systemic sclerosis, scleroderma, Raynauds-phenomenon, survival, epidemiology, metaanalysis, autoimmune-disease, solvents, silica, occupational silica exposure, cigarette-smoking, prevalence, solvent exposure",
author = "Paula Dospinescu and Jones, {Gareth T.} and Neil Basu",
year = "2013",
month = "3",
doi = "10.1097/BOR.0b013e32835cfc2d",
language = "English",
volume = "25",
pages = "179--183",
journal = "Current Opinion in Rheumatology",
issn = "1040-8711",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Environmental risk factors in systemic sclerosis

AU - Dospinescu, Paula

AU - Jones, Gareth T.

AU - Basu, Neil

PY - 2013/3

Y1 - 2013/3

N2 - Purpose of reviewEnvironmental risk factors have been implicated in the pathogenesis of systemic sclerosis (SSc). Recent evidence further supports this relationship and constitutes the focus of this review article.Recent findingsExposure to silica through various occupations remains one of the main environmental risk factors for SSc. Emerging evidence has also implicated organic solvents in the development of this difficult-to-manage condition. The individual role of these toxins is, however, difficult to ascertain due to methodological limitations in study design. Other occupational agents, such as epoxy resins, welding fumes and hand-arm vibration, have been investigated, but no definitive associations may be made due to small sample sizes. The controversial association between silicone breast surgery and SSc has not been proven and, amongst other non-occupational factors, smoking does not increase the risk of development but does appear to impact upon the severity of disease.SummaryA number of environmental exposures are likely to play an important role in the development of the disease; however, current evidence consists mainly of heterogeneous studies with relatively small sample sizes. In the future, multicentre collaborations may help inform preventive strategies.

AB - Purpose of reviewEnvironmental risk factors have been implicated in the pathogenesis of systemic sclerosis (SSc). Recent evidence further supports this relationship and constitutes the focus of this review article.Recent findingsExposure to silica through various occupations remains one of the main environmental risk factors for SSc. Emerging evidence has also implicated organic solvents in the development of this difficult-to-manage condition. The individual role of these toxins is, however, difficult to ascertain due to methodological limitations in study design. Other occupational agents, such as epoxy resins, welding fumes and hand-arm vibration, have been investigated, but no definitive associations may be made due to small sample sizes. The controversial association between silicone breast surgery and SSc has not been proven and, amongst other non-occupational factors, smoking does not increase the risk of development but does appear to impact upon the severity of disease.SummaryA number of environmental exposures are likely to play an important role in the development of the disease; however, current evidence consists mainly of heterogeneous studies with relatively small sample sizes. In the future, multicentre collaborations may help inform preventive strategies.

KW - systemic sclerosis

KW - scleroderma

KW - Raynauds-phenomenon

KW - survival

KW - epidemiology

KW - metaanalysis

KW - autoimmune-disease

KW - solvents

KW - silica

KW - occupational silica exposure

KW - cigarette-smoking

KW - prevalence

KW - solvent exposure

U2 - 10.1097/BOR.0b013e32835cfc2d

DO - 10.1097/BOR.0b013e32835cfc2d

M3 - Literature review

VL - 25

SP - 179

EP - 183

JO - Current Opinion in Rheumatology

JF - Current Opinion in Rheumatology

SN - 1040-8711

IS - 2

ER -