Eosinophil Apoptosis and Clearance in Asthma

Research output: Contribution to journalLiterature review

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Abstract

Asthma is an increasingly common respiratory condition characterized by reversible airway obstruction, bronchial hyperresponsiveness and airway inflammation with a clear unmet need for more effective therapy. Eosinophilic asthma is a phenotype of the condition that features increased blood or sputum eosinophils whose numbers correlate with disease severity. Several lines of evidence are now emerging, which implicate increased persistence of eosinophils in the lungs of patients with asthma as a consequence of inhibition of and defects in the apoptotic process, together with impaired apoptotic cell removal mechanisms. This article will update our knowledge of the mechanisms controlling eosinophil apoptosis and clearance, together with evidence implicating defects in apoptosis and pro-inflammatory cell removal in asthma. Recent developments in novel therapies for asthma that target eosinophil apoptotic and/or clearance pathways will also be discussed.
Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalJournal of Cell Death
Volume6
DOIs
Publication statusPublished - 17 Apr 2013

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Eosinophils
Asthma
Apoptosis
Airway Obstruction
Sputum
Inflammation
Phenotype
Lung
Therapeutics

Keywords

  • eosinophil
  • apoptosis
  • phagocytic removal

Cite this

Eosinophil Apoptosis and Clearance in Asthma. / Walsh, Garry M.

In: Journal of Cell Death, Vol. 6, 17.04.2013, p. 17-25.

Research output: Contribution to journalLiterature review

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