Abstract
The eosinophil has a potent armory of proinflammatory mediators with considerable potential to initiate and sustain an inflammatory response. These Include cytotoxic granule proteins, cytokines, chemokines, and lipid mediators. Eosinophils are considered important in the immune response to infection with helminthic parasitic worms. Incrementally increasing evidence supports a critical role for their proinflammatory activities in diverse human conditions, most notably in allergic diseases such as asthma. In these conditions severe tissue damage is a consequence of an inappropriate accumulation of eosinophils and the subsequent release of their highly toxic granule proteins. In addition, release of granute-associated products such as chemokines and cytokines at the sites of inflammation is likely to have significant paracrine and autocrine relevance. This review will update recent developments in understanding the role that eosinophil granule proteins play in human disease, particularly those of the respiratory tract. (C) 2001 Lippincott Williams & Wilkins, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 28-33 |
| Number of pages | 5 |
| Journal | Current Opinion in Hematology |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2001 |
Keywords
- RESPIRATORY SYNCYTIAL VIRUS
- MAJOR BASIC-PROTEIN
- CATIONIC PROTEIN
- MATRIX METALLOPROTEINASE-9
- AIRWAY HYPERRESPONSIVENESS
- EPITHELIAL-CELLS
- INDUCED ASTHMA
- DEGRANULATION
- INFLAMMATION
- EXPRESSION
Cite this
Eosinophil granule proteins and their role in disease. / Walsh, Garry Michael.
In: Current Opinion in Hematology, Vol. 8, No. 1, 2001, p. 28-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Eosinophil granule proteins and their role in disease
AU - Walsh, Garry Michael
PY - 2001
Y1 - 2001
N2 - The eosinophil has a potent armory of proinflammatory mediators with considerable potential to initiate and sustain an inflammatory response. These Include cytotoxic granule proteins, cytokines, chemokines, and lipid mediators. Eosinophils are considered important in the immune response to infection with helminthic parasitic worms. Incrementally increasing evidence supports a critical role for their proinflammatory activities in diverse human conditions, most notably in allergic diseases such as asthma. In these conditions severe tissue damage is a consequence of an inappropriate accumulation of eosinophils and the subsequent release of their highly toxic granule proteins. In addition, release of granute-associated products such as chemokines and cytokines at the sites of inflammation is likely to have significant paracrine and autocrine relevance. This review will update recent developments in understanding the role that eosinophil granule proteins play in human disease, particularly those of the respiratory tract. (C) 2001 Lippincott Williams & Wilkins, Inc.
AB - The eosinophil has a potent armory of proinflammatory mediators with considerable potential to initiate and sustain an inflammatory response. These Include cytotoxic granule proteins, cytokines, chemokines, and lipid mediators. Eosinophils are considered important in the immune response to infection with helminthic parasitic worms. Incrementally increasing evidence supports a critical role for their proinflammatory activities in diverse human conditions, most notably in allergic diseases such as asthma. In these conditions severe tissue damage is a consequence of an inappropriate accumulation of eosinophils and the subsequent release of their highly toxic granule proteins. In addition, release of granute-associated products such as chemokines and cytokines at the sites of inflammation is likely to have significant paracrine and autocrine relevance. This review will update recent developments in understanding the role that eosinophil granule proteins play in human disease, particularly those of the respiratory tract. (C) 2001 Lippincott Williams & Wilkins, Inc.
KW - RESPIRATORY SYNCYTIAL VIRUS
KW - MAJOR BASIC-PROTEIN
KW - CATIONIC PROTEIN
KW - MATRIX METALLOPROTEINASE-9
KW - AIRWAY HYPERRESPONSIVENESS
KW - EPITHELIAL-CELLS
KW - INDUCED ASTHMA
KW - DEGRANULATION
KW - INFLAMMATION
KW - EXPRESSION
U2 - 10.1097/00062752-200101000-00006
DO - 10.1097/00062752-200101000-00006
M3 - Article
VL - 8
SP - 28
EP - 33
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 1
ER -