Epidemiology Of Angioid Streaks-Associated Choroidal Neovascular Membranes In the United Kingdom

Ehab A Abdelkader, Neil W. Scott, Noemi Lois

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this study is to determine the incidence of angioid streak-associated choroidal neovascular membranes (CNV) in the UK and provide other epidemiological data, clinical characteristics, therapies used, and short-term outcomes following treatment of this condition.

Procedure: This is a prospective multicenter cohort study. Patients newly diagnosed of angioid streaks-associated CNV were identified prospectively over a 14-month period (January 2009-March 2010) by active surveillance through the British Ophthalmic Surveillance Unit (BOSU). Questionnaire-based data was obtained from reporting ophthalmologists at baseline and 12 months. The main outcome measure was incidence of angioid-streak associated CNV. Secondary outcomes included clinical characteristics, treatments used, and visual outcomes.

Results: Forty-four cases of angioid streaks-associated CNV were reported to BOSU giving an annual incidence of 0.057 (95% CI: 0.040-0.074) per 100,000 population. Affected patients had a mean age of 47 years (range: 24-62 years), presented with a mean (SD) LogMAR visual acuity (VA) of 0.53 (0.51) (Snellen equivalent 6/18) and had most often subfoveal CNV. At one year, the mean LogMAR visual acuity had declined to 0.73 (0.59) (Snellen equivalent 6/36). Visual acuity improved > 2 Snellen lines in six cases (21%) and deteriorated > 2 lines in 13 cases (41%). Treatments used included anti-VEGF in 25 eyes (83%), photodynamic therapy (PDT) in two (7%), and observation in three (10%).

Conclusions: This study represents the first population-based prospective study evaluating the incidence of angioid streaks-associated CNV in the UK. Despite new treatments for CNV, the visual outcome of patients with this disorder remains guarded.
Original languageEnglish
Article numbere138
JournalCureus
Volume5
Issue number9
DOIs
Publication statusPublished - 9 Jan 2013

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Angioid Streaks
Epidemiology
Membranes
Visual Acuity
Incidence
Photochemotherapy
Therapeutics
United Kingdom
Vascular Endothelial Growth Factor A
Population
Multicenter Studies
Cohort Studies
Observation
Outcome Assessment (Health Care)
Prospective Studies

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Epidemiology Of Angioid Streaks-Associated Choroidal Neovascular Membranes In the United Kingdom. / Abdelkader, Ehab A; Scott, Neil W.; Lois, Noemi.

In: Cureus, Vol. 5, No. 9, e138, 09.01.2013.

Research output: Contribution to journalArticle

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abstract = "Background: The purpose of this study is to determine the incidence of angioid streak-associated choroidal neovascular membranes (CNV) in the UK and provide other epidemiological data, clinical characteristics, therapies used, and short-term outcomes following treatment of this condition.Procedure: This is a prospective multicenter cohort study. Patients newly diagnosed of angioid streaks-associated CNV were identified prospectively over a 14-month period (January 2009-March 2010) by active surveillance through the British Ophthalmic Surveillance Unit (BOSU). Questionnaire-based data was obtained from reporting ophthalmologists at baseline and 12 months. The main outcome measure was incidence of angioid-streak associated CNV. Secondary outcomes included clinical characteristics, treatments used, and visual outcomes.Results: Forty-four cases of angioid streaks-associated CNV were reported to BOSU giving an annual incidence of 0.057 (95{\%} CI: 0.040-0.074) per 100,000 population. Affected patients had a mean age of 47 years (range: 24-62 years), presented with a mean (SD) LogMAR visual acuity (VA) of 0.53 (0.51) (Snellen equivalent 6/18) and had most often subfoveal CNV. At one year, the mean LogMAR visual acuity had declined to 0.73 (0.59) (Snellen equivalent 6/36). Visual acuity improved > 2 Snellen lines in six cases (21{\%}) and deteriorated > 2 lines in 13 cases (41{\%}). Treatments used included anti-VEGF in 25 eyes (83{\%}), photodynamic therapy (PDT) in two (7{\%}), and observation in three (10{\%}).Conclusions: This study represents the first population-based prospective study evaluating the incidence of angioid streaks-associated CNV in the UK. Despite new treatments for CNV, the visual outcome of patients with this disorder remains guarded.",
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AB - Background: The purpose of this study is to determine the incidence of angioid streak-associated choroidal neovascular membranes (CNV) in the UK and provide other epidemiological data, clinical characteristics, therapies used, and short-term outcomes following treatment of this condition.Procedure: This is a prospective multicenter cohort study. Patients newly diagnosed of angioid streaks-associated CNV were identified prospectively over a 14-month period (January 2009-March 2010) by active surveillance through the British Ophthalmic Surveillance Unit (BOSU). Questionnaire-based data was obtained from reporting ophthalmologists at baseline and 12 months. The main outcome measure was incidence of angioid-streak associated CNV. Secondary outcomes included clinical characteristics, treatments used, and visual outcomes.Results: Forty-four cases of angioid streaks-associated CNV were reported to BOSU giving an annual incidence of 0.057 (95% CI: 0.040-0.074) per 100,000 population. Affected patients had a mean age of 47 years (range: 24-62 years), presented with a mean (SD) LogMAR visual acuity (VA) of 0.53 (0.51) (Snellen equivalent 6/18) and had most often subfoveal CNV. At one year, the mean LogMAR visual acuity had declined to 0.73 (0.59) (Snellen equivalent 6/36). Visual acuity improved > 2 Snellen lines in six cases (21%) and deteriorated > 2 lines in 13 cases (41%). Treatments used included anti-VEGF in 25 eyes (83%), photodynamic therapy (PDT) in two (7%), and observation in three (10%).Conclusions: This study represents the first population-based prospective study evaluating the incidence of angioid streaks-associated CNV in the UK. Despite new treatments for CNV, the visual outcome of patients with this disorder remains guarded.

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