TY - CHAP
T1 - Epithelial barrier function in gut-bone signaling
AU - Rios-Arce, Naiomy Deliz
AU - Collins, Fraser L.
AU - Schepper, Jonathan D.
AU - Steury, Michael D.
AU - Raehtz, Sandi
AU - Mallin, Heather
AU - Schoenherr, Danny T.
AU - Parameswaran, Narayanan
AU - McCabe, Laura R.
PY - 2017
Y1 - 2017
N2 - The intestinal epithelial barrier plays an essential role in maintaining host homeostasis. The barrier regulates nutrient absorption as well as prevents the invasion of pathogenic bacteria in the host. It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases, can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria. In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease. Our lab and others have also shown that barrier disruption can have systemic effects including bone loss. In this chapter, we will discuss the current literature to understand the link between intestinal barrier and bone. We will discuss how inflammation, aging, dysbiosis, and metabolic diseases can affect intestinal barrier-bone link. In addition, we will highlight the current suggested mechanism between intestinal barrier and bone.
AB - The intestinal epithelial barrier plays an essential role in maintaining host homeostasis. The barrier regulates nutrient absorption as well as prevents the invasion of pathogenic bacteria in the host. It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases, can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria. In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease. Our lab and others have also shown that barrier disruption can have systemic effects including bone loss. In this chapter, we will discuss the current literature to understand the link between intestinal barrier and bone. We will discuss how inflammation, aging, dysbiosis, and metabolic diseases can affect intestinal barrier-bone link. In addition, we will highlight the current suggested mechanism between intestinal barrier and bone.
UR - http://www.mendeley.com/research/epithelial-barrier-function-gutbone-signaling
U2 - 10.1007/978-3-319-66653-2_8
DO - 10.1007/978-3-319-66653-2_8
M3 - Chapter
SN - 978-3-319-66651-8
T3 - Advances in Experimental Medicine and Biology
SP - 151
EP - 183
BT - Understanding the Gut-Bone Signaling Axis
A2 - McCabe, Laura R.
A2 - Parameswaran, Narayanan
PB - Springer New York LLC
ER -