Epithelial cells and innate antifungal defense

G Weindl, J Wagener, M Schaller

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46 Citations (Scopus)

Abstract

The human pathogenic fungus Candida albicans is the predominant cause of both superficial and invasive forms of candidiasis. Clinical observations indicate that mucocutaneous Candida infections are commonly associated with defective cell-mediated immune responses. The importance of the innate immune system as a first-line defense against pathogenic challenge has long been recognized. Over the last decade, many key molecules mediating innate host defense have been identified. Central to these developments is the discovery of pattern recognition receptors such as Toll-like receptors and C-type lectin-receptors that induce innate immune responses and also modulate cellular and humoral adaptive immunity during Candida infections. Although a large amount of information is now available in systemic infections, little is known about localized infections. We address the most relevant pattern recognition receptors and their signaling mechanisms in oral epithelial cells, to gain a better understanding of their contributions to antifungal innate immunity.
Original languageEnglish
Pages (from-to)666-675
Number of pages10
JournalJournal of Dental Research
Volume89
Issue number7
Early online date15 Apr 2010
DOIs
Publication statusPublished - Jul 2010

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Keywords

  • adaptive immunity
  • Candida albicans
  • candidiasis, oral
  • epithelial cells
  • humans
  • immunity, innate
  • mouth mucosa
  • receptors, pattern recognition
  • signal transduction
  • T-lymphocytes
  • oral epithelium
  • toll-like receptors
  • C-type lectin-receptors

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