TY - JOUR
T1 - Erucic acid in feed and food
AU - Wallace, Heather
AU - Knutsen, Helle Katrine
AU - Alexander, Jan
AU - Barregård, Lars
AU - Bignami, Margherita
AU - Brüschweiler, Beat
AU - Ceccatelli, Sandra
AU - Dinovi, Michael
AU - Edler, Lutz
AU - Grasl-Kraupp, Bettina
AU - Hogstrand, Christer
AU - Hoogenboom, Laurentius (Ron)
AU - Nebbia, Carlo Stefano
AU - Oswald, Isabelle
AU - Petersen, Annette
AU - Rose, Martin
AU - Roudot, Alain-Claude
AU - Schwerdtle, Tanja
AU - Vollmer, Günter
AU - Cottrill, Bruce
AU - Dogliotti, Eugenia
AU - Laakso, Juha
AU - Metzler, Manfred
AU - Velasco, Leonardo
AU - Baert, Katleen
AU - Gómez Ruiz, Jose Angel
AU - Varga, Enikő
AU - Dörr , Barbara
AU - Vleminckx, Christiane
AU - EFSA Panel on Contaminants in the Food Chain (CONTAM)
N1 - The Panel wishes to thank the members of the Working Group on erucic acid in food and feed: Bruce Cottrill, Eugenia Dogliotti, Juha Laakso, Manfred Metzler, Leonardo Velasco and Christiane Vleminckx for the preparatory work on this scientific output, the hearing expert: Mary Sheppard and EFSA staff members: Katleen Baert, Barbara Dörr, Jose Angel Gomez Ruiz and Enikő Varga for the support provided to this scientific opinion. The Panel acknowledges all European countries and European stakeholder organisations (FEDIOL, SNE and FEFAC) that provided occurrence data on erucic acid in food and feed. The Panel wishes to thank all European countries that supported the collection of consumption data for the Comprehensive European Food Consumption Database.
PY - 2016/11/30
Y1 - 2016/11/30
N2 - Erucic acid is the trivial name of the fatty acid cis-13-docosenoic acid and occurs at high concentrations mainly in the seeds of species of the Brassicaceae (e.g. rape seed or mustard seed). The European Commission requested EFSA to deliver a scientific opinion on the risks for animal and human health related to the presence of erucic acid in feed and food. For most humans, the main contributor to dietary exposure to erucic acid was the food group ‘Fine bakery wares’. In ‘Infants’, ‘Food for infants and small children’ was the main contributor to exposure. The heart is the principal target organ for toxic effects after exposure. Myocardial lipidosis was identified as the critical effect for chronic exposure to erucic acid. This effect is reversible and transient during prolonged exposure. A tolerable daily intake (TDI) of 7 mg/kg body weight (bw) per day for erucic acid was established, based on a no observed adverse effect level of 0.7 g/kg bw per day for lipidosis in young rats and newborn piglets. Mean chronic exposure of the different groups of the population did not exceed the TDI. The 95th percentile dietary exposure level was highest in infants and other children, ranging from 1.3 to 7.4 mg/kg bw per day; the higher level being at the level of the TDI. This may indicate a risk for young individuals with high erucic acid exposure. In pigs, levels of erucic acid are unlikely to represent a health concern. However, for poultry, the small margin between the lowest observed adverse effect level (LOAEL) and the estimated exposure may indicate a health risk where maximum inclusion rates are applied. Due to the absence of adequate data, the risk for ruminants, horses, fish and rabbits could not be assessed.
AB - Erucic acid is the trivial name of the fatty acid cis-13-docosenoic acid and occurs at high concentrations mainly in the seeds of species of the Brassicaceae (e.g. rape seed or mustard seed). The European Commission requested EFSA to deliver a scientific opinion on the risks for animal and human health related to the presence of erucic acid in feed and food. For most humans, the main contributor to dietary exposure to erucic acid was the food group ‘Fine bakery wares’. In ‘Infants’, ‘Food for infants and small children’ was the main contributor to exposure. The heart is the principal target organ for toxic effects after exposure. Myocardial lipidosis was identified as the critical effect for chronic exposure to erucic acid. This effect is reversible and transient during prolonged exposure. A tolerable daily intake (TDI) of 7 mg/kg body weight (bw) per day for erucic acid was established, based on a no observed adverse effect level of 0.7 g/kg bw per day for lipidosis in young rats and newborn piglets. Mean chronic exposure of the different groups of the population did not exceed the TDI. The 95th percentile dietary exposure level was highest in infants and other children, ranging from 1.3 to 7.4 mg/kg bw per day; the higher level being at the level of the TDI. This may indicate a risk for young individuals with high erucic acid exposure. In pigs, levels of erucic acid are unlikely to represent a health concern. However, for poultry, the small margin between the lowest observed adverse effect level (LOAEL) and the estimated exposure may indicate a health risk where maximum inclusion rates are applied. Due to the absence of adequate data, the risk for ruminants, horses, fish and rabbits could not be assessed.
KW - erucic acid
KW - rape seed
KW - rapeseed oil
KW - risk assessment
KW - food
KW - feed
KW - cis-13-docosenoic acid
U2 - 10.2903/j.efsa.2016.4593
DO - 10.2903/j.efsa.2016.4593
M3 - Article
VL - 14
SP - 1
EP - 173
JO - EFSA Journal
JF - EFSA Journal
SN - 1831-4732
IS - 11
M1 - 4593
ER -