Abstract
Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy. A tandem repeat sequence in a TS promoter enhancer region (TSER) was recently identified. Polymorphic variation affected in vitro expression levels of the gene. We evaluated the influence of ethnicity on TSER genotype. Allele frequency was similar in Caucasian and Southwest Asian subjects. However, homozygous triple repeat subjects were tn-ice as common in Chinese subjects (67%) than in Caucasian subjects (38%). This demonstrates significant ethnic variation in a TS gene regulatory element which may have significant impact on pyrimidine homeostasis and drug therapy. (C) 1999 Academic Press.
Original language | English |
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Pages (from-to) | 310-312 |
Number of pages | 3 |
Journal | Genomics |
Volume | 58 |
Issue number | 3 |
DOIs | |
Publication status | Published - 15 Jun 1999 |
Keywords
- thymidylate synthase
- polymorphism
- ethnic groups
- Asian
- pharmacogenetics
- low activity allele
- human gene
- identification
- expression
- frequency
- sequence