Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations

S Marsh, E S R Collie-Duguid, T Li, X H Liu, H L McLeod

Research output: Contribution to journalArticle

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Abstract

Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy. A tandem repeat sequence in a TS promoter enhancer region (TSER) was recently identified. Polymorphic variation affected in vitro expression levels of the gene. We evaluated the influence of ethnicity on TSER genotype. Allele frequency was similar in Caucasian and Southwest Asian subjects. However, homozygous triple repeat subjects were tn-ice as common in Chinese subjects (67%) than in Caucasian subjects (38%). This demonstrates significant ethnic variation in a TS gene regulatory element which may have significant impact on pyrimidine homeostasis and drug therapy. (C) 1999 Academic Press.

Original languageEnglish
Pages (from-to)310-312
Number of pages3
JournalGenomics
Volume58
Issue number3
DOIs
Publication statusPublished - 15 Jun 1999

Keywords

  • thymidylate synthase
  • polymorphism
  • ethnic groups
  • Asian
  • pharmacogenetics
  • low activity allele
  • human gene
  • identification
  • expression
  • frequency
  • sequence

Cite this

Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations. / Marsh, S ; Collie-Duguid, E S R ; Li, T ; Liu, X H ; McLeod, H L .

In: Genomics, Vol. 58, No. 3, 15.06.1999, p. 310-312.

Research output: Contribution to journalArticle

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AU - Collie-Duguid, E S R

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AU - Liu, X H

AU - McLeod, H L

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AB - Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy. A tandem repeat sequence in a TS promoter enhancer region (TSER) was recently identified. Polymorphic variation affected in vitro expression levels of the gene. We evaluated the influence of ethnicity on TSER genotype. Allele frequency was similar in Caucasian and Southwest Asian subjects. However, homozygous triple repeat subjects were tn-ice as common in Chinese subjects (67%) than in Caucasian subjects (38%). This demonstrates significant ethnic variation in a TS gene regulatory element which may have significant impact on pyrimidine homeostasis and drug therapy. (C) 1999 Academic Press.

KW - thymidylate synthase

KW - polymorphism

KW - ethnic groups

KW - Asian

KW - pharmacogenetics

KW - low activity allele

KW - human gene

KW - identification

KW - expression

KW - frequency

KW - sequence

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