Evaluating the association between ccr5delta32 polymorphism (Rs333) and the risk of breast cancer in a cohort of iranian population

Amir Tajbakhsh, Zahra Farjami, Abolfazl Nesaei-Bajestani* (Corresponding Author), Fahimeh Afzaljavan, Mahdi Rivandi, Atefeh Moezzi, Soheila Abedini, Mahla Asghari, Mohammad Mahdi Kooshyar, Fatemeh Homaei Shandiz, Alireza Pasdar* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: CC chemokine receptor 5 (CCR5) is introduced as an immune response modulator. The activi-ty of CCR5 influences breast tumour development in a p53-dependent manner. This study aimed to investigate the frequency of CCR5delta32 and its association with the risk of breast cancer in 1038 blood samples in North East of Iran. Methods: In this case-control study, we genotyped 570 control samples and 468 breast cancer patients by a gel electrophoresis-based gap-polymerase chain reaction (gap-PCR) method Mashhad, Iran. The data were analyzed using the SPSS software. Results: Of 570 controls included, 542 (95.09%) had CCR5delta32wild/wild (W/W) genotype, 28 samples (4.91%) had CCR5delta32wild/deletion (W/D) genotype and none of them were CCR5delta32deletion/deletion (D/D) genotype (0%). While 428 samples of patients (91.45%) had CCR5delta32W/W genotype, 40 samples (8.55%) had CCR5delta32 W/D and CCR5delta32D/D homozygous was nil (0%) amongst cases. All samples were in the Hardy–Weinberg equilibrium (P>0.05). According to the allele frequency, D allele, as a risky allele, in the cases was more than the control samples (0.0427 vs 0.0245, respectively) (P=0.0206). Hence, W/D genotype may confer a risk effect (OR=1.77, CI: 1.09-2.90; P=0.0206) compared with WW genotype between case and control groups. Conclusion: There is a statistically significant association between CCR5W/D and breast cancer risk. CCR5 may be regarded as a target for the prevention of breast cancer in certain conditions such as interaction with p53 variants, which remains to be further investigated.

Original languageEnglish
Pages (from-to)583-591
Number of pages9
JournalIranian Journal of Public Health
Volume50
Issue number3
Publication statusPublished - 1 Mar 2021

Keywords

  • Breast carcinoma
  • CCR5D32
  • Immunogenetics
  • Metastasis
  • P53 pathway

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