Evaluation of corneal graft rejection in a mouse model

Jarka Plskova, Lucia Kuffova, V. Holan, M. Filipec, John Vincent Forrester

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Corneal graft rejection presents clinically and in experimental models as opacification and is considered to be the result of endothelial cell dysfunction or loss. However, recovery from opacification can occur suggesting either (a) that new endothelial cells can regenerate if the original cells were lost, or (b) that sufficient numbers of original cells can regain function if the opacification was due to temporary dysfunction. In this perspective, previous experimental studies of allograft rejection plus some new data are reviewed to support the latter mechanism.

Original languageEnglish
Pages (from-to)108-113
Number of pages5
JournalBritish Journal of Ophthalmology
Volume86
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • ALLOGRAFT SURVIVAL
  • PENETRATING KERATOPLASTY
  • IMMUNOLOGICAL PRIVILEGE
  • MURINE MODEL
  • INBRED RAT
  • T-CELL
  • TRANSPLANTATION
  • MICE
  • RESPONSES
  • ANTIGENS

Cite this