Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential

Gregory I. Giles, Fiona H. Fry, Karen M. Tasker, Andrea L. Holme, Chris Peers, Kim N. Green, Lars Oliver Klotz, Helmut Sies, Claus Jacob*

*Corresponding author for this work

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Oxidative stress is implicated, either directly or indirectly, in the pathology of a range of human diseases. As a consequence, the development of efficient antioxidants for medical use has become increasingly important. We have synthesized a range of structurally related organo-sulfur, -selenium and -tellurium agents and demonstrated that a combination of electrochemical methodology, in vitro assays and cell culture tests can be used to rationalise the antioxidant activity of these catalytic agents. Based on its exceptionally low anodic oxidation potential (Epa) and high activity against the representative oxidative stressors tert-butyl hydroperoxide and peroxynitrite, 4,4′-dihydroxydiphenyltelluride is predicted to be a potent antioxidant. This compound exhibits a correspondingly high activity with a remarkably low IC50 value of 20 nM, when tested in PC12 cell culture using a bioassay indicative of the early stages of Alzheimer's disease.

Original languageEnglish
Pages (from-to)4317-4322
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number23
DOIs
Publication statusPublished - 7 Dec 2003

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    Giles, G. I., Fry, F. H., Tasker, K. M., Holme, A. L., Peers, C., Green, K. N., Klotz, L. O., Sies, H., & Jacob, C. (2003). Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential. Organic and Biomolecular Chemistry, 1(23), 4317-4322. https://doi.org/10.1039/b308117f