Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers: results from the consortium of investigators of modifiers of BRCA1/BRCA2

A Osorio, R L Milne, R Alonso, G Pita, P Peterlongo, A Teulé, K L Nathanson, S M Domchek, T Rebbeck, A Lasa, I Konstantopoulou, F B Hogervorst, S Verhoef, M F van Dooren, A Jager, M G E M Ausems, C M Aalfs, C J van Asperen, M Vreeswijk, Q WaisfiszC E Van Roozendaal, M J Ligtenberg, D F Easton, S Peock, M Cook, C T Oliver, D Frost, B Curzon, D G Evans, F Lalloo, R Eeles, L Izatt, R Davidson, J Adlard, D Eccles, K-r Ong, F Douglas, S Downing, C Brewer, L Walker, H Nevanlinna, K Aittomäki, F J Couch, Z Fredericksen, N M Lindor, A Godwin, C Isaacs, M A Caligo, N Loman, HEBON, Zosia Miedzybrodzka

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Abstract

Single-nucleotide polymorphisms (SNPs) in genes involved in DNA repair are good candidates to be tested as phenotypic modifiers for carriers of mutations in the high-risk susceptibility genes BRCA1 and BRCA2. The base excision repair (BER) pathway could be particularly interesting given the relation of synthetic lethality that exists between one of the components of the pathway, PARP1, and both BRCA1 and BRCA2. In this study, we have evaluated the XRCC1 gene that participates in the BER pathway, as phenotypic modifier of BRCA1 and BRCA2.
Original languageEnglish
Pages (from-to)1356-1361
Number of pages6
JournalBritish Journal of Cancer
Volume104
Issue number8
Early online date22 Mar 2011
DOIs
Publication statusPublished - 12 Apr 2011

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Osorio, A., Milne, R. L., Alonso, R., Pita, G., Peterlongo, P., Teulé, A., Nathanson, K. L., Domchek, S. M., Rebbeck, T., Lasa, A., Konstantopoulou, I., Hogervorst, F. B., Verhoef, S., van Dooren, M. F., Jager, A., Ausems, M. G. E. M., Aalfs, C. M., van Asperen, C. J., Vreeswijk, M., ... Miedzybrodzka, Z. (2011). Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers: results from the consortium of investigators of modifiers of BRCA1/BRCA2. British Journal of Cancer, 104(8), 1356-1361. https://doi.org/10.1038/bjc.2011.91