Evidence for Fas counter attack in vivo from a study of colorectal cancer

E Arbuckle, N E I Langlois, O Eremin, S D Heys

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis. However, tumours may mount a 'counter-attack' by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes. This study used immunohistochemistry to demonstrate the presence of CD8(+) lymphocytes and Fas ligand. The score of CD8(+) peritumoural lymphocytes was negatively correlated with the Fas ligand score of the tumour. The results provide evidence for the Fas 'counter-attack' theory, but further work would be required to determine if this is a significant factor in the tumour-host interaction.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalOncology Reports
Volume7
Publication statusPublished - 2000

Keywords

  • colorectal cancer
  • CD95
  • tumour infiltrating lymphocytes
  • TUMOR-INFILTRATING LYMPHOCYTES
  • RECTAL-CANCER
  • CELLS
  • COLON
  • APOPTOSIS
  • CLASSIFICATION
  • MECHANISMS
  • CARCINOMA
  • ANTIBODY
  • LIGAND

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