Evidence for Fas counter attack in vivo from a study of colorectal cancer

E Arbuckle, N E I Langlois, O Eremin, S D Heys

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis. However, tumours may mount a 'counter-attack' by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes. This study used immunohistochemistry to demonstrate the presence of CD8(+) lymphocytes and Fas ligand. The score of CD8(+) peritumoural lymphocytes was negatively correlated with the Fas ligand score of the tumour. The results provide evidence for the Fas 'counter-attack' theory, but further work would be required to determine if this is a significant factor in the tumour-host interaction.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalOncology Reports
Volume7
Publication statusPublished - 2000

Keywords

  • colorectal cancer
  • CD95
  • tumour infiltrating lymphocytes
  • TUMOR-INFILTRATING LYMPHOCYTES
  • RECTAL-CANCER
  • CELLS
  • COLON
  • APOPTOSIS
  • CLASSIFICATION
  • MECHANISMS
  • CARCINOMA
  • ANTIBODY
  • LIGAND

Cite this

Arbuckle, E., Langlois, N. E. I., Eremin, O., & Heys, S. D. (2000). Evidence for Fas counter attack in vivo from a study of colorectal cancer. Oncology Reports, 7, 45-47.

Evidence for Fas counter attack in vivo from a study of colorectal cancer. / Arbuckle, E ; Langlois, N E I ; Eremin, O ; Heys, S D .

In: Oncology Reports, Vol. 7, 2000, p. 45-47.

Research output: Contribution to journalArticle

Arbuckle, E, Langlois, NEI, Eremin, O & Heys, SD 2000, 'Evidence for Fas counter attack in vivo from a study of colorectal cancer', Oncology Reports, vol. 7, pp. 45-47.
Arbuckle E, Langlois NEI, Eremin O, Heys SD. Evidence for Fas counter attack in vivo from a study of colorectal cancer. Oncology Reports. 2000;7:45-47.
Arbuckle, E ; Langlois, N E I ; Eremin, O ; Heys, S D . / Evidence for Fas counter attack in vivo from a study of colorectal cancer. In: Oncology Reports. 2000 ; Vol. 7. pp. 45-47.
@article{4a0cbcaeb91d4b19aaea267a8d6f6194,
title = "Evidence for Fas counter attack in vivo from a study of colorectal cancer",
abstract = "Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis. However, tumours may mount a 'counter-attack' by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes. This study used immunohistochemistry to demonstrate the presence of CD8(+) lymphocytes and Fas ligand. The score of CD8(+) peritumoural lymphocytes was negatively correlated with the Fas ligand score of the tumour. The results provide evidence for the Fas 'counter-attack' theory, but further work would be required to determine if this is a significant factor in the tumour-host interaction.",
keywords = "colorectal cancer, CD95, tumour infiltrating lymphocytes, TUMOR-INFILTRATING LYMPHOCYTES, RECTAL-CANCER, CELLS, COLON, APOPTOSIS, CLASSIFICATION, MECHANISMS, CARCINOMA, ANTIBODY, LIGAND",
author = "E Arbuckle and Langlois, {N E I} and O Eremin and Heys, {S D}",
year = "2000",
language = "English",
volume = "7",
pages = "45--47",
journal = "Oncology Reports",
issn = "1021-335X",
publisher = "Spandidos Publications",

}

TY - JOUR

T1 - Evidence for Fas counter attack in vivo from a study of colorectal cancer

AU - Arbuckle, E

AU - Langlois, N E I

AU - Eremin, O

AU - Heys, S D

PY - 2000

Y1 - 2000

N2 - Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis. However, tumours may mount a 'counter-attack' by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes. This study used immunohistochemistry to demonstrate the presence of CD8(+) lymphocytes and Fas ligand. The score of CD8(+) peritumoural lymphocytes was negatively correlated with the Fas ligand score of the tumour. The results provide evidence for the Fas 'counter-attack' theory, but further work would be required to determine if this is a significant factor in the tumour-host interaction.

AB - Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis. However, tumours may mount a 'counter-attack' by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes. This study used immunohistochemistry to demonstrate the presence of CD8(+) lymphocytes and Fas ligand. The score of CD8(+) peritumoural lymphocytes was negatively correlated with the Fas ligand score of the tumour. The results provide evidence for the Fas 'counter-attack' theory, but further work would be required to determine if this is a significant factor in the tumour-host interaction.

KW - colorectal cancer

KW - CD95

KW - tumour infiltrating lymphocytes

KW - TUMOR-INFILTRATING LYMPHOCYTES

KW - RECTAL-CANCER

KW - CELLS

KW - COLON

KW - APOPTOSIS

KW - CLASSIFICATION

KW - MECHANISMS

KW - CARCINOMA

KW - ANTIBODY

KW - LIGAND

M3 - Article

VL - 7

SP - 45

EP - 47

JO - Oncology Reports

JF - Oncology Reports

SN - 1021-335X

ER -